Serum Neuron-Specific Enolase Level as Predictor of Neurologic Outcome after Aortic Surgery

• Material Type: 博士論文
• Title: Serum Neuron-Specific Enolase Level as Predictor of Neurologic Outcome after Aortic Surgery
• Author/Editor: 木村, 文昭
• Publication Date: 2019-01
• Publication Date (W3CDTF): 2019-01
• Alternative Title: 大血管手術後における神経学的予後予測因子としての血清神経特異的エノラ－ゼ値
• Periodical title: Thoracic and Cardiovascular Surgeon
• Degree grantor/type: 旭川医科大学
• Date Granted: 2019-03-25
• Date Granted (W3CDTF): 2019-03-25
• Dissertation Number: 甲第530号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第530号
• Text Language Code: eng
• Subject Heading: serum neuron-specific enolase; thoracic aortic surgery; temporary neurologic dysfunction; permanent neurologic dysfunction; neurologic injury
• Note (General): BACKGROUND: This study aimed to evaluate the significance of serum neuron-specific enolase (NSE) level as a predictor of neurologic injury in thoracic aortic surgery. METHODS: We neurologically assessed 60 consecutive patients who underwent thoracic aortic surgery for thoracic aortic aneurysm (n = 26) and aortic dissection (n = 34). Using moderate hypothermic circulatory arrest with antegrade cerebral perfusion, total arch replacement and hemiarch replacement were performed in 37 and 23 patients, respectively. Serum NSE levels in venous blood samples drawn before surgery and at 1 day after surgery were measured. Severity of neurologic injury was categorized as either uncomplicated (n = 48), temporary neurologic dysfunction (TND, n = 5), or permanent neurologic dysfunction (PND, n = 7). The extent of stroke was estimated on computed tomography or magnetic resonance imaging. RESULTS: The NSE level significantly differed among the three groups (PND > TND > uncomplicated) on the first postoperative day. Receiver-operating characteristic curve analysis showed that the cutoff value of NSE level was 34.14 ng/mL for neurologic injury (sensitivity, 0.769; specificity, 0.851) and 43.56 ng/mL for PND (sensitivity, 1.000; specificity, 0.963). The NSE level significantly correlated with the extent of stroke (r = 0.61, p < 0.001). CONCLUSION: Serum NSE level is a significant predictor of adverse neurologic outcomes and extent of stroke after thoracic aortic surgery.; identifier:PMID：30669174
• DOI: info:doi/10.1055/s-0038-1677511; https://doi.org/info:doi/10.1055/s-0038-1677511
• Persistent ID (NDL): info:ndljp/pid/11278854; https://dl.ndl.go.jp/pid/11278854
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-05-06T10:27:56+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20190325_K530
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp