敗血症患者の循環ヒストンH3レベルは、凝固障害、多臓器不全、および死亡と関連している : 単一施設観察研究

• Material Type: 博士論文
• Title: 敗血症患者の循環ヒストンH3レベルは、凝固障害、多臓器不全、および死亡と関連している : 単一施設観察研究
• Volume: 17
• Author/Editor: 横山, 弥生
• Author Heading: 横山, 弥生
• Publication, Distribution, etc.: BMC
• Publication Date: 2019; 17
• Publication Date (W3CDTF): 2019
• Alternative Title: Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study
• Periodical title: Thrombosis Journal
• Degree grantor/type: 鹿児島大学
• Date Granted: 2019-03-25
• Date Granted (W3CDTF): 2019-03-25
• Dissertation Number: 甲総研第498号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Conferring No. (Dissertation): 甲総研第498号
• Text Language Code: eng
• Subject Heading: Histone; Sepsis; Coagulopathy; Organ failure
• NDC: 493
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Background: Nuclear histone proteins are released into the extracellular space, and act as major mediators of coagulopathy and remote organ failure in septic animals. However, the circulating histone levels in septic patients have not been precisely quantified.Methods: Using a novel enzyme-linked immunosorbent assay for histone H3 detection, we measured the serum histone H3 levels in 85 patients admitted to the intensive care unit because of infectious diseases. We then evaluated the associations of circulating histone H3 levels with organ failure, coagulopathy, and mortality.Results: Circulating histone H3 levels were significantly higher in patients with coagulopathy, and were positively correlated with numbers of organ failures. Circulating histone H3 levels were also associated with fatal outcome. Receiver-operating characteristic analyses revealed that the predictive performance of circulating histone H3 levels for mortality was higher than that of conventional inflammatory markers, including white blood cell count, C-reactive protein, and cell-free DNA.Conclusions: Circulating histone H3 levels are associated with coagulopathy, multiple organ failure, and death in patients requiring intensive care because of infectious diseases.
• DOI: info:doi/10.1186/s12959-018-0190-4; https://doi.org/info:doi/10.1186/s12959-018-0190-4
• Persistent ID (NDL): info:ndljp/pid/11279021; https://dl.ndl.go.jp/pid/11279021
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-05-06T10:27:56+09:00
• Date Created (W3CDTF): 2019-04-17
• Format (IMT): PDF; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): https://thrombosisjournal.biomedcentral.com/
• Periodical Title (URI): http://hdl.handle.net/10232/00030535
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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