膵管腺癌における分子病態 : Pre-miR-148aのパッセンジャー鎖が遺伝子調節に及ぼす影響。

• Material Type: 博士論文
• Title: 膵管腺癌における分子病態 : Pre-miR-148aのパッセンジャー鎖が遺伝子調節に及ぼす影響。
• Volume: 109 6
• Author/Editor: 伊地知, 徹也
• Author Heading: 伊地知, 徹也
• Publication, Distribution, etc.: Japanese Cancer Association
• Publication Date: 2018; 109 6
• Publication Date (W3CDTF): 2018
• Alternative Title: Molecular pathogenesis of pancreatic ductal adenocarcinoma : impact of passenger strand of pre-miR-148a on gene regulation
• Periodical title: Cancer Science
• Degree grantor/type: 鹿児島大学
• Date Granted: 2019-03-25
• Date Granted (W3CDTF): 2019-03-25
• Dissertation Number: 甲総研第502号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Conferring No. (Dissertation): 甲総研第502号
• Text Language Code: eng
• Subject Heading: cancer genome/genetics; characteristics and pathology of human cancer; information; invasion and metastasis; oncogenes and tumor-suppressor genes
• NDC: 493
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; We previously used RNA sequencing to establish the microRNA (miRNA) expression signature of pancreatic ductal adenocarcinoma (PDAC). We found that both strands of pre-miR-148a (miR-148a-5p: the passenger strand and miR-148a-3p: the guide strand) were downregulated in cancer tissues. Ectopic expression of miR-148a-5p and miR-148a-3p significantly inhibited cancer cell migration and invasion, indicating that both strands of pre-miR-148a had tumor-suppressive roles in PDAC cells. In silico database and genome-wide gene expression analyses identified a total of 15 genes that were putative targets regulated by these miRNAs. High expression of miR-148a-5p targets (PHLDA2, LPCAT2 and AP1S3) and miR-148a-3p targets (SMA, ENDOD1 and UHMK1) was associated with poor prognosis of patients with PDAC. Moreover, knockdown of PHLDA2 expression inhibited cancer cell aggressiveness, suggesting PHLDA2 acted as an oncogene in PDAC cells. Involvement of the passenger strand of pre-miR-148a (miR-148-5p) is a new concept in cancer research. Novel approaches that identify tumor-suppressive miRNA regulatory networks in lethal PDAC might provide new prognostic markers and therapeutic targets for this disease.
• DOI: info:doi/10.1111/cas.13610; https://doi.org/info:doi/10.1111/cas.13610
• Persistent ID (NDL): info:ndljp/pid/11279023; https://dl.ndl.go.jp/pid/11279023
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-05-06T10:27:56+09:00
• Date Created (W3CDTF): 2019-04-17
• Format (IMT): PDF; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): https://onlinelibrary.wiley.com/journal/13497006#pane-01cbe741-499a-4611-874e-1061f1f4679e01
• Related Material: text
• Periodical Title (URI): http://hdl.handle.net/10232/00030539
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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