Endogenous progesterone levels could predict reproductive outcome in frozen embryo replacement cycles supplemented with synthetic progestogens : A retrospective cohort study

• Material Type: 博士論文
• ISSN: 1447-0578
• Title: Endogenous progesterone levels could predict reproductive outcome in frozen embryo replacement cycles supplemented with synthetic progestogens : A retrospective cohort study
• Volume: 18 1
• Author/Editor: Kawachiya, Satoshi; Bodri, Daniel; Hirosawa, Toshikazu; Serna, Jazmina Yao; Kuwahara, Akira; Irahara, Minoru
• Author Heading: Kawachiya, Satoshi; Bodri, Daniel; Hirosawa, Toshikazu; Serna, Jazmina Yao; Kuwahara, Akira; Irahara, Minoru
• Publication, Distribution, etc.: Wiley|Japan Society for Reproductive Medicine
• Publication Date: 2018-11-01
• Publication Date (W3CDTF): 2018-11-01
• Alternative Title: 内因性プロゲステロン分泌は、合成プロゲステロン製剤を用いたホルモン補充凍結胚移植周期において妊娠予後予測因子になり得る
• Periodical title: Reproductive Medicine and Biology
• Degree grantor/type: 徳島大学
• Date Granted: 2019-02-06
• Date Granted (W3CDTF): 2019-02-06
• Dissertation Number: 甲第3252号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3252号
• Text Language Code: eng
• Subject Heading: progesterone; blastocyst transfer; fertilization in vitro; single embryo transfer; luteoplacental shift; dydrogesterone; placental progesterone
• Target Audience: 一般
• Note (General): Purpose: A retrospective, cohort study was conducted between 2009 and 2017 in a private infertility center to determine the predictive value of endogenous estrogen (E2) and progesterone (P4) levels in hormone‐replacement frozen embryo replacement (FER) treatment cycles.Methods: A total of 120 consecutive, infertile patients who became pregnant after FER cycles were analyzed (age: 37.4 ± 4.4 years). Electively vitrified blastocysts were created during natural cycle IVF or mild ovarian stimulation treatments and subsequently transferred through delayed vitrified‐thawed blastocyst transfer cycles supplemented with estrogens and a combination of synthetic progestogens. Serum E2 and progesterone P4 levels were intensively monitored every five days (from the day after embryo transfer until 9w1d of pregnancy) and compared among patients with a subsequent live birth (n = 76) or first‐trimester pregnancy loss (n = 44).Results: Endogenous placental activity started as early as 5‐6th pregnancy week differing significantly according to pregnancy outcome. For P4, the exponential rise from 6w2d onwards allowed distinguishing between failing and successful conceptions. For P4, lower quartiles of the live birth group did not intersect with upper quartiles of the miscarriage group.Conclusions: Innovative FER protocols incorporating synthetic progestogens allow the correct measurement of endogenous placental activity and could help to monitor early first‐trimester ART pregnancies.
• DOI: info:doi/10.1002/rmb2.12254; https://doi.org/info:doi/10.1002/rmb2.12254
• Persistent ID (NDL): info:ndljp/pid/11279084; https://dl.ndl.go.jp/pid/11279084
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-05-06T10:27:56+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/113269
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp