Intraperitoneal administration of activin A promotes development of endometriotic lesions in a mouse model of endometriosis

• Material Type: 博士論文
• ISSN: 1349-6867
• Title: Intraperitoneal administration of activin A promotes development of endometriotic lesions in a mouse model of endometriosis
• Volume: 66 1-2
• Author/Editor: Kasai, Kana; Kato, Takeshi; Kadota, Yuri; Erdenebayar, Otgontsetseg; Keyama, Kaoru; Kawakita, Takako; Yoshida, Kanako; Kuwahara, Akira; Matsuzaki, Toshiya; Irahara, Minoru
• Author Heading: Kasai, Kana; Kato, Takeshi; Kadota, Yuri; Erdenebayar, Otgontsetseg; Keyama, Kaoru; Kawakita, Takako; Yoshida, Kanako; Kuwahara, Akira; Matsuzaki, Toshiya; Irahara, Minoru
• Publication, Distribution, etc.: Tokushima University Faculty of Medicine
• Publication Date: 2019-02
• Publication Date (W3CDTF): 2019-02
• Alternative Title: 子宮内膜症モデルマウスにおいてアクチビンの腹腔内投与は子宮内膜症様病変の増殖を促進する; Activin A promotes endometriotic lesions
• Periodical title: The Journal of Medical Investigation
• Degree grantor/type: 徳島大学
• Date Granted: 2019-02-06
• Date Granted (W3CDTF): 2019-02-06
• Dissertation Number: 甲第3253号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3253号
• Text Language Code: eng
• Subject Heading: Endometriosis; Activin A; Mouse model; Inflammatory cytokine
• Target Audience: 一般
• Note (General): PURPOSE : This study aimed to investigate the effect of intraperitoneal administration of activin on the occurrence of endometriosis using a mouse model of endometriosis. METHODS : A mouse model of endometriosis was prepared by intraperitoneally administering endometrial tissue and blood collected from donor mice to C57BL/6J 7-8- week-old recipient mice. A total of 400 μg of activin A was intraperitoneally administered to model mice in the activin group for 5 days. Intraperitoneal endometriotic lesions were confirmed macroscopically and IL-6 and TNF-α levels in washed ascites were measured by ELISA. RESULTS : Endometriotic lesions were observed in all mice. In the activin group, the maximum diameter of endometriotic lesions was significantly larger than that in control group (4.7±1.3 vs 2.9±0.9 mm, p<0.01). The total area of the lesion was also significantly higher in the activin group than in the control group (21.1±9.9 vs 8.8±5.4 mm2, p<0.01). Furthermore, IL-6 and TNF-α levels in ascites were significantly higher in the activin group than in the control group (IL-6 : 85.8±15.3 vs 75.1±19.3 pg/ml, p<0.05 ; TNF-α : 629.8±15.4 vs 605.9±11.4 pg/ml, p<0.05). CONCLUSION : Activin promotes occurrence of endometriosis. Inflammatory cytokines are also elevated by activin administration,suggesting that they may contribute to progression of endometriosis
• DOI: info:doi/10.2152/jmi.66.123; https://doi.org/info:doi/10.2152/jmi.66.123
• Persistent ID (NDL): info:ndljp/pid/11279085; https://dl.ndl.go.jp/pid/11279085
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-05-06T10:27:56+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/113270
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2019-09-04 再収集