Macular atrophy findings by optical coherence tomography angiography compared with fundus autofluorescence in treated exudative age-related macular degeneration

• Material Type: 博士論文
• Title: Macular atrophy findings by optical coherence tomography angiography compared with fundus autofluorescence in treated exudative age-related macular degeneration
• Author/Editor: 高砂, 縁
• Author Heading: 高砂, 縁
• Publication Date: 2019-03-24
• Publication Date (W3CDTF): 2019-03-24
• Degree grantor/type: 香川大学
• Date Granted: 2019-03-24
• Date Granted (W3CDTF): 2019-03-24
• Dissertation Number: 甲第709号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第709号
• Text Language Code: eng
• Alias of Author: Takasago, Yukari
• Subject Heading: macular atrophy; choriocapillaris nonperfusion; fundus autofluorescence; optical coherence tomography angiography; exudative age-related macular degeneration; choroidal ischemia
• Target Audience: 一般
• Note (General): Purpose: To compare the areas of choriocapillaris (CC) nonperfusion and macular atrophy (MA) in treated exudative age-related macular degeneration.; Methods: This was a prospective, observational, cross-sectional study. Forty-four eyes exhibiting MA (42 patients with age-related macular degeneration), with a dry macula, underwent fundus autofluorescence and optical coherence tomography angiography. The area of MA detected by fundus autofluorescence and CC nonperfusion detected by optical coherence tomography angiography was measured using image analysis software. The rates of concordance between the MA and CC nonperfusion areas were calculated. We qualitatively and quantitatively compared the areas of MA and CC nonperfusion in age-related macular degeneration eyes.; Results: The mean areas of MA and CC nonperfusion were 5.95 ± 4.50 mm and 10.66 ± 7.05 mm, respectively (paired t-test, P < 0.001). In 39 eyes (88.6%), the CC nonperfusion area was larger than the MA area, and the mean CC nonperfusion area was significantly larger than the mean MA area. Fundus autofluorescence matching optical coherence tomography angiography showed that the CC nonperfusion area was almost included in the MA area. The mean concordance rate for the MA area inside the CC nonperfusion area was 87.7 ± 13.9%.; Conclusion: The MA and CC nonperfusion areas markedly overlapped. The area of CC nonperfusion correlated with the MA area. Choroidal ischemia might be involved in the pathogenesis of MA in treated age-related macular degeneration.
• DOI: info:doi/10.1097/IAE.0000000000001980; https://doi.org/info:doi/10.1097/IAE.0000000000001980
• Persistent ID (NDL): info:ndljp/pid/11279135; https://dl.ndl.go.jp/pid/11279135
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-05-06T10:27:56+09:00
• Date Created (W3CDTF): 2020-10-27
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/353
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp