共生性渦鞭毛藻類の二次代謝のゲノム科学的洞察

• Material Type: 博士論文
• Title: 共生性渦鞭毛藻類の二次代謝のゲノム科学的洞察
• Author/Editor: Beedessee, Girish
• Author Heading: Beedessee, Girish
• Publication Date: 2019-04-30
• Publication Date (W3CDTF): 2019-04-30
• Alternative Title: Genomic insights on secondary metabolism in symbiotic dinoflagellates
• Degree grantor/type: Okinawa Institute of Science and Technology Graduate University
• Date Granted: 2019-04-30
• Date Granted (W3CDTF): 2019-04-30
• Dissertation Number: 甲第33号
• Degree Type: Doctor of Philosophy
• Conferring No. (Dissertation): 甲第33号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): Dinoflagellates (division Pyrrhophyta, class Dinophyceae) are an important group of phytoplankton found in a wide range of environment reflecting a remarkable diversity in form and nutrition styles. They are typically unicellular, photosynthetic, free-swimming and form part of freshwater, brackish and marine phytoplankton communities. Dinoflagellates also produce a wide variety of secondary metabolites including toxins that are dangerous to man, marine animals, fish and other member of food chains. At present, the only available genomes of dinoflagellates are that of the family Symbiodiniaceae. Decoding higher order dinoflagellates remains a challenge because of their large nuclear genomes (up to 250 Gbp). Dinoflagellates highlight the extent of divergence that has taken place in the evolution of eukaryotic life. Taking together the economical, ecological and evolutionary importance of dinoflagellates, undertaking their genome sequencing is a valuable venture. For these reasons, this dissertation aims at understanding how the chemical diversity arises in the family Symbiodiniaceae and explain what evolutionary drivers contribute to this diversity. Next, I decode the genome of a basal dinoflagellate, Amphidinium gibossum, known to produce interesting small molecules of biological importance. The purpose of this new genome was to investigate if A. gibossum secondary metabolism differs from that of the family Symbiodiniaceae. I found that the underlying chemistry is similar, and I attempt to explain how specialized enzymes generate unique chemical diversity in them. Lastly, I focus on how nutrient starvation affect secondary metabolism in A. gibossum. In several dinoflagellates, phosphate and nitrate stress are known to increase or decrease toxin production, but the underlying transcriptomic mechanism remains limited. During such stress conditions, expression of membrane transporters for import of specific ions is upregulated and expression of secondary metabolism is correlated with nutrient availability, involving the action of miRNAs.
• DOI: 10.15102/1394.00000779; https://doi.org/10.15102/1394.00000779
• Persistent ID (NDL): info:ndljp/pid/11287899; https://dl.ndl.go.jp/pid/11287899
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-06-03T12:31:31+09:00
• Date Created (W3CDTF): 2019-05-10
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://dx.doi.org/10.15102/1394.00000779; https://oist.repo.nii.ac.jp/records/860
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

Table of Contents

2023-09-04 再収集

2023-09-04 再収集