Down-regulated expression of human leukocyte antigen class I heavy chains is linked to poor prognosis in non-small cell lung cancer

• Material Type: 博士論文
• Title: Down-regulated expression of human leukocyte antigen class I heavy chains is linked to poor prognosis in non-small cell lung cancer
• Author/Editor: 市之川, 一臣
• Author Heading: 市之川, 一臣
• Publication, Distribution, etc.: Hokkaido University
• Publication Date: 2017-03-23
• Publication Date (W3CDTF): 2017-03-23
• Alternative Title: 非小細胞肺癌においてHLA Class I H鎖の発現低下は予後不良と相関している
• Contributor: 松野, 吉宏; 秋田, 弘俊; 平野, 聡
• Degree grantor/type: 北海道大学
• Date Granted: 2017-03-23
• Date Granted (W3CDTF): 2017-03-23
• Dissertation Number: 甲第12529号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲第12529号
• Text Language Code: eng
• Subject Heading: HLA class I antigen; β2-microglobulin antigen; non-small-cell lung cancer; immunohistochemistry
• NDC: 490
• Target Audience: 一般
• Note (General): 配架番号：2270; The aim of this study was to clarify the associations between expression of human leukocyte antigen (HLA) class I on non-small-cell lung cancer (NSCLC) cells, and patient survival. To address this, immunohistochemical staining for HLA class I was performed on specimens from 111 patients with NSCLC, and overall survival curves were compared using the log-rank test. In addition, multivariate analyses were undertaken using Cox's proportional hazard model. The cases were divided into five classes based on expression of HLA class I heavy chain and β2-microglobulin. Overall survival for patients with tumors lacking HLA class I heavy chain (30 cases; 27.0%) was significantly compromised. Multivariate analysis revealed the absence of HLA class I heavy chain to be an independent predictor of poor prognosis. There was a trend towards unfavorable prognosis for those patients whose tumors did not express β2-microglobulin (57 cases; 51.4%). Down-regulation of HLA class I heavy chain expression significantly correlated with down-regulation of β2-microglobulin expression (χ2; 44 p<0.01). Cases lacking both HLA class I heavy chain and β2-microglobulin expression (23 cases; 20.7%) had a statistically significant unfavorable prognosis compared with other cases (p<0.05). Our data demonstrate that lack of HLA class I heavy chain expression in tumor cells is an independent poor prognostic factor for NSCLC survival, and is likely to have an important influence on immune surveillance in patients.; (主査) 教授 松野 吉宏, 教授 秋田 弘俊, 教授 平野 聡; 医学研究科（癌医学専攻）
• DOI: 10.14943/doctoral.k12529; https://doi.org/10.14943/doctoral.k12529
• Persistent ID (NDL): info:ndljp/pid/11288174; https://dl.ndl.go.jp/pid/11288174
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-06-03T12:31:31+09:00
• Date Created (W3CDTF): 2017-03
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://dx.doi.org/10.14943/doctoral.k12529; http://hdl.handle.net/2115/74363
• Is Referenced By (URI): http://hdl.handle.net/2115/65865
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• Summary, etc.: The aim of this study was to clarify the associations between expression of human leukocyte antigen (HLA) class I on non-small-cell lung cancer (NSCLC...