The Efficacy of Programmed Intermittent Epidural Bolus for Postoperative Analgesia after Open Gynecological Surgery : A Randomized Double-Blinded Study

• Material Type: 博士論文
• ISSN: 2314-6133
• Title: The Efficacy of Programmed Intermittent Epidural Bolus for Postoperative Analgesia after Open Gynecological Surgery : A Randomized Double-Blinded Study
• Volume: 2018
• Author/Editor: Satomi, Shiho; Kakuta, Nami; Murakami, Chiaki; Sakai, Yoko; Tanaka, Katsuya; Tsutsumi, Yasuo M.
• Author Heading: Satomi, Shiho; Kakuta, Nami; Murakami, Chiaki; Sakai, Yoko; Tanaka, Katsuya; Tsutsumi, Yasuo M.
• Publication, Distribution, etc.: Hindawi
• Publication Date: 2018-05-15
• Publication Date (W3CDTF): 2018-05-15
• Alternative Title: 開腹婦人科手術での術後鎮痛における硬膜外間欠投与の有効性
• Periodical title: BioMed Research International
• Degree grantor/type: 徳島大学
• Date Granted: 2019-03-22
• Date Granted (W3CDTF): 2019-03-22
• Dissertation Number: 甲第3250号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3250号
• Text Language Code: eng
• Subject Heading: General anesthesia; Open surgery; PIEB
• Target Audience: 一般
• Note (General): Background. It is well known that the programmed intermittent epidural bolus (PIEB) technique effectively provides epidural anesthesia in labor. This randomized double-blind trial compared the postoperative analgesic efficacy of PIEB with that of continuous epidural infusion (CEI) in patients undergoing gynecological surgery under combined general-epidural anesthesia. Methods. Patients undergoing open gynecological surgery under combined general-epidural anesthesia were randomized at a 1 : 1 ratio to receive PIEB or CEI. In the PIEB group, the pump delivered 4mL ropivacaine 0.2% plus fentanyl 2 ?g/mL every hour. In the CEI group, the pump delivered the same solution at a rate of 4 mL/h. In both groups, additional 4mL boluses of ropivacaine 0.2% plus fentanyl 2 ?g/mL were provided, when necessary, by patient-controlled epidural analgesia after surgery. The primary outcome was the total ropivacaine dose 40 hours after surgery. The secondary outcomes were the number of PCEA boluses and postoperative pain (evaluated on an 11-point numerical rating scale) 3, 24, and 48 hours after surgery. Results. In total, 57 patients were randomized (? = 28 and 29 in the PIEB and CEI groups, resp.). The two groups differ significantly in terms of the total ropivacaine dose 40 hours after surgery (mean (standard deviation): 155.38 (4.55) versus 159.73 (7.87) mL, ? = 0.016). Compared to the CEI group, the PIEB group had significantly lower numerical rating scale scores 3 hours (median [lower–upper quartiles]: 0 [0–0.5] versus 3 [0–5.5], ? = 0.002), 24 hours (1 [0–2] versus 3 [1–4], ? = 0.003), and 48 hours (1 [0–2] versus 2 [2–3.5], ? = 0.002) after surgery. Conclusion. PIEB was better than CEI in terms of providing postoperative analgesia after open gynecological surgery under combined general-epidural anesthesia.
• DOI: info:doi/10.1155/2018/6297247; https://doi.org/info:doi/10.1155/2018/6297247
• Persistent ID (NDL): info:ndljp/pid/11300290; https://dl.ndl.go.jp/pid/11300290
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-07-05T01:13:02+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/113336
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp