Acceleration of tumor growth due to dysfunction in M1 macrophages and enhanced angiogenesis in an animal model of autoimmune disease

• Material Type: 博士論文
• ISSN: 1530-0307
• Title: Acceleration of tumor growth due to dysfunction in M1 macrophages and enhanced angiogenesis in an animal model of autoimmune disease
• Volume: 96 4
• Author/Editor: Kondo, Tomoyuki; Tsunematsu, Takaaki; Yamada, Akiko; Arakaki, Rieko; Saito, Masako; Otsuka, Kunihiro; Kujiraoka, Satoko; Ushio, Aya; Kurosawa, Mie; Kudo, Yasusei; Ishimaru, Naozumi
• Author Heading: Kondo, Tomoyuki; Tsunematsu, Takaaki; Yamada, Akiko; Arakaki, Rieko; Saito, Masako; Otsuka, Kunihiro; Kujiraoka, Satoko; Ushio, Aya; Kurosawa, Mie; Kudo, Yasusei; Ishimaru, Naozumi
• Publication, Distribution, etc.: Springer nature
• Publication Date: 2016-01-25
• Publication Date (W3CDTF): 2016-01-25
• Alternative Title: 自己免疫疾患モデルにおけるM1マクロファージ不全と血管新生を介した腫瘍増殖の亢進; Cross-talk between autoimmunity and tumor immunity
• Periodical title: Laboratory Investigation
• Degree grantor/type: 徳島大学
• Date Granted: 2016-03-23
• Date Granted (W3CDTF): 2016-03-23
• Dissertation Number: 甲第2943号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第2943号
• Text Language Code: eng
• Subject Heading: Autoimmunity; Cancer; Tumor associated macrophage; Angiogenesis; Tumor immunity
• Target Audience: 一般
• Note (General): Both autoimmunity and tumor immunity are immune responses against self-tissues or cells. However, the precise similarity or difference between them remains unclear. In this study, to understand a novel mechanism of tumor immunity, we performed transplantation experiments with a murine autoimmune model, C57BL/6J (B6)/lpr mice. A melanoma cell line, B16F10 cells, or granulocyte macrophage colony-stimulating factor- overexpressing B16F10 (B16F10/mGM) cells were transplanted into B6 or B6/lpr mice. Tumor growth by transplanted B16F10/mGM cells was significantly accelerated in B6/lpr mice compared with that in B6 mice. The accumulation of M1 macrophages in the tumor tissues of B6/lpr recipient mice was significantly lower compared with that in the control mice. In vitro co-culture experiment showed that impaired differentiation into M1 macrophages was observed in B6/lpr mice. The number of tumor vessels and vascular endothelial growth factor (VEGF) expression were also significantly enhanced in the tumor tissues of B6/lpr mice compared with those in the B6 mice. Moreover, VEGF expression was correlated with the increased expression of hypoxia-inducible factor-1α in the tumor tissues of B6/lpr mice. These results suggest that dysfunctional tumor immunity and enhanced angiogenesis in autoimmunity influence tumor growth.
• DOI: info:doi/10.1038/labinvest.2015.166; https://doi.org/info:doi/10.1038/labinvest.2015.166
• Persistent ID (NDL): info:ndljp/pid/11301790; https://dl.ndl.go.jp/pid/11301790
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-07-05T01:13:02+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/109707
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp