Hyaluronan metabolism in overloaded temporomandibular joint

• Material Type: 博士論文
• ISSN: 0305-182X
• Title: Hyaluronan metabolism in overloaded temporomandibular joint
• Volume: 43 12
• Author/Editor: Shinohara, Takehiro; Izawa, Takashi; Mino-Oka, Akiko; Mori, Hiroki; Iwasa, Akihiko; Inubushi, Toshihiro; Yamaguchi, Y; Tanaka, Eiji
• Author Heading: Shinohara, Takehiro; Izawa, Takashi; Mino-Oka, Akiko; Mori, Hiroki; Iwasa, Akihiko; Inubushi, Toshihiro; Yamaguchi, Y; Tanaka, Eiji
• Publication, Distribution, etc.: John Wiley & Sons
• Publication Date: 2016-09-14
• Publication Date (W3CDTF): 2016-09-14
• Alternative Title: 過剰負荷を受けた顎関節におけるヒアルロン酸代謝の検討; Hyaluronan metabolism in overloaded TMJ
• Periodical title: Journal of Oral Rehabilitation
• Degree grantor/type: 徳島大学
• Date Granted: 2017-03-23
• Date Granted (W3CDTF): 2017-03-23
• Dissertation Number: 甲第3073号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第3073号
• Text Language Code: eng
• Subject Heading: Hyaluronan; temporomandibular joint; osteoarthritis
• Target Audience: 一般
• Note (General): The present study aimed to examine hyaluronan (HA) metabolism in relation to the onset and progression of temporomandibular joint osteoarthritis (TMJ-OA) induced by mechanical overloading. Two-month-old and 6-month-old C57BL/6N mice were divided into experimental and untreated control groups (n = 5/group). A sliding plate was attached to the maxillary incisors of the experimental mice for 10 days to overload the condylar cartilage in TMJ. In experimental group, profound cartilage degradation was detected in hematoxylin-eosin, Safranin-O-Fast Green stained sections. It was also shown that the cartilage degradation was greater in older mice in both the control and the experimental groups. The number of HABP positive cells was decreased by mechanical overloading and with age. The reduction of HA expression was correlated with the progression of cartilage degradation induced by mechanical overloading. The absolute quantification of the mRNA expression related to HA synthesis and HA degradation was also performed in each group. The mRNA expression levels of HA synthase (HAS) 2 and 3 were lower in the experimental group compared with the control group in the younger mice. In contrast, the mRNA expression levels of the HA degradation gene, HYAL2 and KIAA1199, were higher in the experimental group compared with the control group in the older mice. Thus, mechanical overload differently affected the balance of HA degradation and HA synthesis in the older and younger mice, respectively. In conclusion, mechanical overloading affects HA metabolism and it might initiate or amplify the condylar cartilage degradation.
• DOI: info:doi/10.1111/joor.12443; https://doi.org/info:doi/10.1111/joor.12443
• Persistent ID (NDL): info:ndljp/pid/11301792; https://dl.ndl.go.jp/pid/11301792
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-07-05T01:13:02+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/110120
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp