Profile of microRNAs associated with aging in rat liver

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Profile of microRNAs associated with aging in rat liver

Persistent ID (NDL): info:ndljp/pid/11336309

Material type: 博士論文

Author: 三村, 志麻

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Publication date: 2014-06-25

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: AbstractRecent studies suggest that small non‑coding microRNAs (miRNAs or miRs) play an important role in the regulation of genes involved in various ...

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Material Type: 博士論文
Title: Profile of microRNAs associated with aging in rat liver
Author/Editor: 三村, 志麻
Author Heading: 三村, 志麻
Publication Date: 2014-06-25
Publication Date (W3CDTF): 2014-06-25
Degree grantor/type: 香川大学
Date Granted: 2014-06-25
Date Granted (W3CDTF): 2014-06-25
Dissertation Number: 甲第595号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第595号
Text Language Code: eng
Alias of Author: Mimura, Shima
Target Audience: 一般
Note (General): AbstractRecent studies suggest that small non‑coding microRNAs (miRNAs or miRs) play an important role in the regulation of genes involved in various cellular and developmental processes. However, the expression of miRNAs during the aging process remains largely unknown. The aim of the present study was to analyze miRNA expression profiles in rat livers during the aging process. The livers of male Wistar rats at different stages of development (fetal, aged 3 days, and 1, 2, 4, 8 and 36 weeks of age) were used. Total RNA was extracted from the livers. We analyzed the expression levels of 679 rat miRNA probes. In addition, immunohistochemical staining for proliferating cell nuclear antigen (PCNA) was performed. Several up- and downregulated miRNAs were identified in the rat livers at 7 different fetal developmental stages and at 36 weeks of age. We observed the upregulation of miR‑29a, miR‑29c, miR‑195 and miR‑497, whereas miR‑301a, miR‑148b-3p, miR‑7a, miR‑93, miR‑106b, miR‑185, miR‑450a, miR‑539 and miR‑301b were downregulated in the aging rat livers. The number of PCNA-positive hepatocytes was decreased with age. In conclusion, our findings suggest that these up- and downregulated miRNAs play an important role in aging by regulating cell cycles that are involved in liver senescence. Further investigation is required to reveal additional target genes of the miRNAs expressed in the liver and the roles of miRNAs in the developmental process of aging in the liver.
DOI: info:doi/10.3892/ijmm.2014.1892
https://doi.org/info:doi/10.3892/ijmm.2014.1892
Persistent ID (NDL): info:ndljp/pid/11336309
https://dl.ndl.go.jp/pid/11336309
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2019-08-03T12:23:27+09:00
Date Created (W3CDTF): 2020-10-27
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/227
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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