Evaluation of bilirubin displacement effect by acetaminophen in vitro

Persistent ID (NDL): info:ndljp/pid/11337524

Material type: 博士論文

Author: 杉野, 政城

Publisher: -

Publication date: 2016-03-24

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 香川大学,博士（医学）

View All

Notes on use at the National Diet Library

本資料は、掲載誌(URI)等のリンク先にある学位授与機関のWebサイトやCiNii Dissertationsから、本文を自由に閲覧できる場合があります。

Notes on use

Note (General)：: Background: The use of acetaminophen as a drug for pain control is expected to increase in the neonatal field. The displacement factor of acetaminophe...

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 博士論文
Title: Evaluation of bilirubin displacement effect by acetaminophen in vitro
Author/Editor: 杉野, 政城
Author Heading: 杉野, 政城
Publication Date: 2016-03-24
Publication Date (W3CDTF): 2016-03-24
Degree grantor/type: 香川大学
Date Granted: 2016-03-24
Date Granted (W3CDTF): 2016-03-24
Dissertation Number: 甲第620号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第620号
Text Language Code: eng
Alias of Author: Sugino, Masashiro
Subject Heading: Erythrocyte-bound bilirubin
unbound bilirubin
glucose oxidase peroxidase method
accelerator
sulfisoxazole
Target Audience: 一般
Note (General): Background: The use of acetaminophen as a drug for pain control is expected to increase in the neonatal field. The displacement factor of acetaminophen in the reaction in the glucose oxidase peroxidase method is very high, but is also considered to be inaccurate based on physicochemical properties.
Method: Unbound bilirubin was measured using the erythrocyte-bound bilirubin measurement method and glucose oxidase peroxidase method by the addition of acetaminophen or sulfisoxazole. The displacement factor was measured using glucose oxidase peroxidase method with the addition of tert-butyl-p-hydroxyanisole.
Results: Acetaminophen did not increase erythrocyte-bound bilirubin, and the addition of tert-butyl-p-hydroxyanisole lowered its displacement factor. On the other hand, sulfisoxazole increased erythrocyte-bound bilirubin, while tert-butyl-p-hydroxyanisole did not change its displacement factor.
Conclusion: Acetaminophen is an accelerator of the reaction in the glucose oxidase peroxidase method and does not displace bilirubin from human serum albumin.
DOI: info:doi/10.1177/0004563214567477
https://doi.org/info:doi/10.1177/0004563214567477
Persistent ID (NDL): info:ndljp/pid/11337524
https://dl.ndl.go.jp/pid/11337524
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2019-08-03T12:23:27+09:00
Date Created (W3CDTF): 2020-10-27
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/374
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp