Urinary Angiotensinogen Could be a Prognostic Marker of Renoprotective Effects of Alogliptin in Patients with Type 2 Diabetes

Persistent ID (NDL): info:ndljp/pid/11337597

Material type: 博士論文

Author: 水重, 知子

Publisher: -

Publication date: 2016-03-24

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: Background: The aims of this study were (1) to examine the renoprotective effects of alogliptin and (2) to establish urinary angiotensinogen (AGT) as ...

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Material Type: 博士論文
Title: Urinary Angiotensinogen Could be a Prognostic Marker of Renoprotective Effects of Alogliptin in Patients with Type 2 Diabetes
Author/Editor: 水重, 知子
Author Heading: 水重, 知子
Publication Date: 2016-03-24
Publication Date (W3CDTF): 2016-03-24
Degree grantor/type: 香川大学
Date Granted: 2016-03-24
Date Granted (W3CDTF): 2016-03-24
Dissertation Number: 甲第629号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第629号
Text Language Code: eng
Alias of Author: Mizushige, Tomoko
Target Audience: 一般
Note (General): Background: The aims of this study were (1) to examine the renoprotective effects of alogliptin and (2) to establish urinary angiotensinogen (AGT) as a prognostic marker of renoprotective effects of alogliptin in patients with type 2 diabetes (T2D).
Methods: In 43 patients with T2D (18 women, 66.1 ± 1.71 years), 25 mg/day of alogliptin was added to the traditional hypoglycemic agents and/or nondrug treatments. Urinary concentrations of albumin (Alb) and AGT, normalized by urinary concentrations of creatinine (Cr) (UAlbCR and UAGTCR, respectively), were measured before and after the 12-week alogliptin treatment.
Results: Alogliptin treatment tended to decrease UAlbCR (99.6 ± 26.8 versus 114.6 ± 36.0 mg/g Cr, P = 0.198). Based on % change in UAlbCR, patients were divided into two groups, responders (< -25%) and nonresponders (≥ -25%), and a logistic analysis of UAGTCR before treatment showed cutoff value of 20.8 µg/g Cr. When all patients were redivided into two groups, those with higher values of UAGTCR before the treatment (Group H, n = 20) and those with lower values (Group L), Group H showed significantly decreased UAlbCR in response to alogliptin (-14.6 ± 8.6 versus +22.8 ± 16.8%, P = 0.033).
Conclusion: Urinary AGT could be a prognostic marker of renoprotective effects of alogliptin in patients with T2D.
DOI: info:doi/10.1155/2015/517472
https://doi.org/info:doi/10.1155/2015/517472
Persistent ID (NDL): info:ndljp/pid/11337597
https://dl.ndl.go.jp/pid/11337597
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2019-08-03T12:23:27+09:00
Date Created (W3CDTF): 2020-10-27
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/383
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