Galectin-9 suppresses the proliferation of gastric cancer cells in vitro

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DOI[info:doi/10.3892/or.2015.4452]to the data of the same series

Galectin-9 suppresses the proliferation of gastric cancer cells in vitro

Persistent ID (NDL): info:ndljp/pid/11337598

Material type: 博士論文

Author: 髙野, 実子

Publisher: -

Publication date: 2016-03-24

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: AbstractGastric cancer is the second-leading cause of cancer-related mortality worldwide, and the prognosis of advanced gastric cancer remains poor. G...

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Material Type: 博士論文
Title: Galectin-9 suppresses the proliferation of gastric cancer cells in vitro
Author/Editor: 髙野, 実子
Author Heading: 髙野, 実子
Publication Date: 2016-03-24
Publication Date (W3CDTF): 2016-03-24
Degree grantor/type: 香川大学
Date Granted: 2016-03-24
Date Granted (W3CDTF): 2016-03-24
Dissertation Number: 甲第637号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第637号
Text Language Code: eng
Alias of Author: Takano, Jitsuko
Subject Heading: caspase-cleaved keratin 18
gastric cancer
galectin-9
apoptosis
microRNAs
insulin-like growth factor 1 receptor
angiogenesis
Target Audience: 一般
Note (General): AbstractGastric cancer is the second-leading cause of cancer-related mortality worldwide, and the prognosis of advanced gastric cancer remains poor. Galectin-9 (Gal-9) is a tandem-repeat-type galectin that has recently been demonstrated to exert anti-proliferative effects on various types of cancer cells. The aim of our present study was to evaluate the effects of Gal-9 on human gastric cancer cells and the expression levels of microRNAs (miRNAs) associated with the antitumor effects of Gal-9 in vitro. In our initial experiments, Gal-9 suppressed the proliferation of gastric cancer cell lines in vitro. Our data further revealed that Gal-9 increased caspase-cleaved keratin 18 (CCK18) levels in gastric cancer cells. Additionally, Gal-9 reduced the phosphorylation of vascular endothelial growth factor receptor-3 (VEGFR-3) and insulin-like growth factor-1 receptor (IGF-1R). Furthermore, miRNA expression levels were markedly altered with Gal-9 treatment in vitro. In conclusion, Gal-9 suppressed the proliferation of human gastric cancer cells by inducing apoptosis. These findings suggest that Gal-9 could be a potential therapeutic target in the treatment of gastric cancer.
DOI: info:doi/10.3892/or.2015.4452
https://doi.org/info:doi/10.3892/or.2015.4452
Persistent ID (NDL): info:ndljp/pid/11337598
https://dl.ndl.go.jp/pid/11337598
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2019-08-03T12:23:27+09:00
Date Created (W3CDTF): 2020-10-27
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/391
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp