Placental pathology predicts infantile physical development during first 18 months in Japanese population: Hamamatsu birth cohort for mothers and children (HBC Study)

• Material Type: 博士論文
• ISSN: 1932-6203
• Title: Placental pathology predicts infantile physical development during first 18 months in Japanese population: Hamamatsu birth cohort for mothers and children (HBC Study)
• Volume: 13 4
• Author/Editor: 谷口, 千津子
• Author Heading: 谷口, 千津子
• Publication, Distribution, etc.: PLOS (Public Library of Science)
• Publication Date: 2018-04-10
• Publication Date (W3CDTF): 2018-04-10
• Alternative Title: 胎盤病理は日本人乳幼児の18か月間の身体発育を予測する：浜松母と子の出生コホート研究
• Periodical title: PLOS ONE
• Degree grantor/type: 浜松医科大学
• Date Granted: 2018-09-21
• Date Granted (W3CDTF): 2018-09-21
• Dissertation Number: 乙第554号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第554号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; The present study aimed to investigate the relationship between placental pathological findings and physiological development during the neonate and infantile periods. Study participants were 258 infants from singleton pregnancies enrolled in the Hamamatsu Birth Cohort for Mothers and Children (HBC Study) whose placentas were stored in our pathological division. They were followed up from birth to 18 months of age. Physiological development (body weight and the ponderal index [PI]) was assessed at 0, 1, 4, 6, 10, 14, and 18 months. Placental blocks were prepared by random sampling and eleven pathological findings were assessed, as follows: ‘Accelerated villous maturation’, ‘Decidual vasculopathy’, ‘Thrombosis or Intramural fibrin deposition’, ‘Avascular villi’, ‘Delayed villous maturation’, ‘Maternal inflammatory response’, ‘Fetal inflammatory response’, ‘Villitis of unknown etiology (VUE)’, ‘Deciduitis’, ‘Maternal vascular malperfusion’, and ‘Fetal vascular malperfusion’. Mixed model analysis with the use of the xtmixed command by the generic statistical software, Stata version 13.1., identified ‘Accelerated villous maturation’ and ‘Maternal vascular malperfusion’ as significant predictors of a lower body weight and ‘Deciduitis’ as a significant predictor of a small PI, throughout the first 18 months of life. In conclusion, the present study is the first to demonstrate that some pathological findings of the placenta are associated with changes in infantile physical development during the initial 18 months of life in the Japanese population.
• DOI: info:doi/10.1371/journal.pone.0194988; https://doi.org/info:doi/10.1371/journal.pone.0194988
• Persistent ID (NDL): info:ndljp/pid/11337734; https://dl.ndl.go.jp/pid/11337734
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-08-03T12:23:27+09:00
• Date Created (W3CDTF): 2019-07-09
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003566; https://hama-med.repo.nii.ac.jp/records/3426
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-09 再収集