Role of caveolin-1 in hepatocellular carcinoma arising from non-alcoholic fatty liver disease

• Material Type: 博士論文
• ISSN: 1347-9032
• Title: Role of caveolin-1 in hepatocellular carcinoma arising from non-alcoholic fatty liver disease
• Volume: 109 8
• Author/Editor: 武田, 真
• Author Heading: 武田, 真
• Publication, Distribution, etc.: Wiley Publishing on behalf of the Japanese Cancer Association
• Publication Date: 2018-06-13
• Publication Date (W3CDTF): 2018-06-13
• Alternative Title: 非アルコール性脂肪性肝疾患から発生する肝細胞がんにおけるcaveolin-1の役割
• Periodical title: Cancer Science
• Degree grantor/type: 浜松医科大学
• Date Granted: 2019-01-18
• Date Granted (W3CDTF): 2019-01-18
• Dissertation Number: 甲第789号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第789号
• Text Language Code: eng
• Subject Heading: apoptosis; caveolin-1; ceramide; hepatocellular carcinoma; non-alcoholic fatty liver disease
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; The molecular features of hepatocellular carcinoma arising from non-alcoholic fatty liver disease (NAFLD-HCC) are not well known. In this study, we investigated the mechanism by which NAFLD-HCC survives in a fat-rich environment. We found that caveolin (CAV)-1 was overexpressed in clinical specimens from NAFLD-HCC patients. HepG2, HLE, and HuH-7 HCC cell lines showed decreased proliferation in the presence of the saturated fatty acids palmitic acid and stearic acid, although only HLE cells expressed high levels of CAV-1. HLE cells treated with oleic acid (OA) showed robust proliferation, whereas CAV-null HepG2 cells showed reduced proliferation and increased apoptosis. CAV-1 knockdown in HLE cells attenuated the OA-induced increase in proliferation and enhanced apoptosis. Liquid chromatography-tandem mass spectrometry analysis revealed that the levels of OA-containing ceramide, a pro-apoptotic factor, were higher in HepG2 and CAV-1-deficient HLE cells than in HLE cells, suggesting that CAV-1 inhibits apoptosis by decreasing the level of OA-containing ceramide. These results indicate that CAV-1 is important for NAFLD-HCC survival in fatty acid-rich environments and is a potential therapeutic target.
• DOI: info:doi/10.1111/cas.13659; https://doi.org/info:doi/10.1111/cas.13659
• Persistent ID (NDL): info:ndljp/pid/11337736; https://dl.ndl.go.jp/pid/11337736
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-08-03T12:23:27+09:00
• Date Created (W3CDTF): 2019-07-09
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003568; https://hama-med.repo.nii.ac.jp/records/3428
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-09 再収集