A power law distribution of metabolite abundance levels in mice regardless of the time and spatial scale of analysis 1

• Material Type: 博士論文
• ISSN: 2045-2322
• Title: A power law distribution of metabolite abundance levels in mice regardless of the time and spatial scale of analysis
• Volume: 8 1
• Author/Editor: 佐藤, 駿平
• Author Heading: 佐藤, 駿平
• Publication, Distribution, etc.: Nature Publishing Group
• Publication Date: 2018-07-09
• Publication Date (W3CDTF): 2018-07-09
• Alternative Title: マウス組織における解析の時空間に依存しない代謝物存在量のべき分布
• Periodical title: SCIENTIFIC REPORTS
• Degree grantor/type: 浜松医科大学
• Date Granted: 2019-01-18
• Date Granted (W3CDTF): 2019-01-18
• Dissertation Number: 甲第790号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第790号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Biomolecule abundance levels change with the environment and enable a living system to adapt to the new conditions. Although, the living system maintains at least some characteristics, e.g. homeostasis. One of the characteristics maintained by a living system is a power law distribution of biomolecule abundance levels. Previous studies have pointed to a universal characteristic of biochemical reaction networks, with data obtained from lysates of multiple cells. As a result, the spatial scale of the data related to the power law distribution of biomolecule abundance levels is not clear. In this study, we researched the scaling law of metabolites in mouse tissue with a spatial scale of quantification that was changed stepwise between a whole-tissue section and a single-point analysis (25 μm). As a result, metabolites in mouse tissues were found to follow the power law distribution independently of the spatial scale of analysis. Additionally, we tested the temporal changes by comparing data from younger and older mice. Both followed similar power law distributions, indicating that metabolite composition is not diversified by aging to disrupt the power law distribution. The power law distribution of metabolite abundance is thus a robust characteristic of a living system regardless of time and space.
• DOI: info:doi/10.1038/s41598-018-28667-5; https://doi.org/info:doi/10.1038/s41598-018-28667-5
• Persistent ID (NDL): info:ndljp/pid/11337737; https://dl.ndl.go.jp/pid/11337737
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-08-03T12:23:27+09:00
• Date Created (W3CDTF): 2019-07-09
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003569; https://hama-med.repo.nii.ac.jp/records/3429
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-09 再収集