IL-10 and CXCL2 in trigeminal ganglia in neuropathic pain

• Material Type: 博士論文
• Title: IL-10 and CXCL2 in trigeminal ganglia in neuropathic pain
• Volume: 703
• Author/Editor: Iwasa, Takuma; Afroz, Shaista; Inoue, Miho; Arakaki, Rieko; Oshima, Masamitsu; Raju, Resmi; Waskitho, Arief; Inoue, Masahisa; Baba, Otto; Matsuka, Yoshizo
• Author Heading: Iwasa, Takuma; Afroz, Shaista; Inoue, Miho; Arakaki, Rieko; Oshima, Masamitsu; Raju, Resmi; Waskitho, Arief; Inoue, Masahisa; Baba, Otto; Matsuka, Yoshizo
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2019-03-20
• Publication Date (W3CDTF): 2019-03-20
• Alternative Title: 神経障害性疼痛における三叉神経筋内のIL-10とCXCL2
• Periodical title: Neuroscience Letters
• Degree grantor/type: 徳島大学
• Date Granted: 2019-06-13
• Date Granted (W3CDTF): 2019-06-13
• Dissertation Number: 甲第3317号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第3317号
• Text Language Code: eng
• Subject Heading: Orofacial pain; Neuropathic pain; Sensory ganglia; Glial cell; Cytokine; Chemokine
• Target Audience: 一般
• Note (General): Many trigeminal neuropathic pain patients suffer severe chronic pain. The neuropathic painmight be related with cross-excitation of the neighboring neurons and satellite glial cell (SGCs) in the sensory ganglia and increasing the pain signals from the peripheral tissue to the central nervous system. We induced trigeminal neuropathic pain by infraorbital nerve constriction injury (IONC) in Sprague-Dawley rats. We tested cytokine (CXCL2 and IL-10) levels in trigeminal ganglia (TGs) after trigeminal neuropathic pain induction, and the effect of direct injection of the anti-CXCL2 and recombinant IL-10 into TG. We found that IONC induced pain behavior. Additionally, IONC induced satellite glial cell activation in TG and cytokine levels of TGs were changed after IONC. CXCL2 levels increased on day 1 of neuropathic pain induction and decreased gradually, with IL-10 levels showing the opposite trend. Recombinant IL-10 or anti-CXCL2 injection into TG decreased pain behavior. Our results show that IL-10 or anti-CXCL2 are therapy options for neuropathic pain.
• DOI: info:doi/10.1016/j.neulet.2019.03.031; https://doi.org/info:doi/10.1016/j.neulet.2019.03.031
• Persistent ID (NDL): info:ndljp/pid/11361578; https://dl.ndl.go.jp/pid/11361578
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-10-04T14:36:02+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/113686
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp