IL-10 and CXCL2 in trigeminal ganglia in neuropathic pain

Persistent ID (NDL): info:ndljp/pid/11361578

Material type: 博士論文

Author: Iwasa, Takumaほか

Publisher: Elsevier

Publication date: 2019-03-20

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（歯学）

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Note (General)：: Many trigeminal neuropathic pain patients suﬀer severe chronic pain. The neuropathic painmight be related with cross-excitation of the neighboring neu...

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Digital

Material Type: 博士論文
ISSN: 0304-3940
Title: IL-10 and CXCL2 in trigeminal ganglia in neuropathic pain
Volume: 703
Author/Editor: Iwasa, Takuma
Afroz, Shaista
Inoue, Miho
Arakaki, Rieko
Oshima, Masamitsu
Raju, Resmi
Waskitho, Arief
Inoue, Masahisa
Baba, Otto
Matsuka, Yoshizo
Author Heading: Iwasa, Takuma
Afroz, Shaista
Inoue, Miho
Arakaki, Rieko
Oshima, Masamitsu
Raju, Resmi
Waskitho, Arief
Inoue, Masahisa
Baba, Otto
Matsuka, Yoshizo
Publication, Distribution, etc.: Elsevier
Publication Date: 2019-03-20
Publication Date (W3CDTF): 2019-03-20
Alternative Title: 神経障害性疼痛における三叉神経筋内のIL-10とCXCL2
Periodical title: Neuroscience Letters
Degree grantor/type: 徳島大学
Date Granted: 2019-06-13
Date Granted (W3CDTF): 2019-06-13
Dissertation Number: 甲第3317号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第3317号
Text Language Code: eng
Subject Heading: Orofacial pain
Neuropathic pain
Sensory ganglia
Glial cell
Cytokine
Chemokine
Target Audience: 一般
Note (General): Many trigeminal neuropathic pain patients suﬀer severe chronic pain. The neuropathic painmight be related with cross-excitation of the neighboring neurons and satellite glial cell (SGCs) in the sensory ganglia and increasing the pain signals from the peripheral tissue to the central nervous system. We induced trigeminal neuropathic pain by infraorbital nerve constriction injury (IONC) in Sprague-Dawley rats. We tested cytokine (CXCL2 and IL-10) levels in trigeminal ganglia (TGs) after trigeminal neuropathic pain induction, and the eﬀect of direct injection of the anti-CXCL2 and recombinant IL-10 into TG. We found that IONC induced pain behavior. Additionally, IONC induced satellite glial cell activation in TG and cytokine levels of TGs were changed after IONC. CXCL2 levels increased on day 1 of neuropathic pain induction and decreased gradually, with IL-10 levels showing the opposite trend. Recombinant IL-10 or anti-CXCL2 injection into TG decreased pain behavior. Our results show that IL-10 or anti-CXCL2 are therapy options for neuropathic pain.
DOI: info:doi/10.1016/j.neulet.2019.03.031
https://doi.org/info:doi/10.1016/j.neulet.2019.03.031
Persistent ID (NDL): info:ndljp/pid/11361578
https://dl.ndl.go.jp/pid/11361578
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2019-10-04T14:36:02+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/113686
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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