Prognostic significance of GAD1 overexpression in patients with resected lung adenocarcinoma 9

• Material Type: 博士論文
• ISSN: 2045-7634
• Title: Prognostic significance of GAD1 overexpression in patients with resected lung adenocarcinoma
• Volume: 8 9
• Author/Editor: Tsuboi, Mitsuhiro; Kondo, Kazuya; Masuda, Kiyoshi; Tange, Shoichiro; Kajiura, Koichiro; Kohmoto, Tomohiro; Takizawa, Hiromitsu; Imoto, Issei; Tangoku, Akira
• Author Heading: Tsuboi, Mitsuhiro; Kondo, Kazuya; Masuda, Kiyoshi; Tange, Shoichiro; Kajiura, Koichiro; Kohmoto, Tomohiro; Takizawa, Hiromitsu; Imoto, Issei; Tangoku, Akira
• Publication, Distribution, etc.: John Wiley & Sons, Ltd
• Publication Date: 2019-06-17
• Publication Date (W3CDTF): 2019-06-17
• Alternative Title: 肺腺癌患者の予後予測におけるGAD1過剰発現の有用性
• Periodical title: Cancer Medicine
• Degree grantor/type: 徳島大学
• Date Granted: 2019-07-25
• Date Granted (W3CDTF): 2019-07-25
• Dissertation Number: 甲第3321号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3321号
• Text Language Code: eng
• Subject Heading: GAD1; lung adenocarcinoma; expression; prognosis; DNA methylation
• Target Audience: 一般
• Note (General): Background and Objectives: In a previous genome-wide screening, we identified hypermethylated CpG islands around glutamate decarboxylase 1 (GAD1) in lung adenocarcinoma (LADC). In this study, we aimed to investigate the methylation and expression status of GAD1 and its prognostic value in patients with LADC.Methods: GAD1 methylation and mRNA expression status were analyzed using 33 tumorous and paired non-tumorous LADC samples and publicly available datasets. The prognostic value of GAD1 overexpression was investigated using publicly available datasets of mRNA levels and 162 cases of LADC by immunohistochemistry.Results: The methylation and mRNA expression levels of GAD1, each having a positive correlation, were significantly higher in LADC tumors than in paired non-tumorous tissues. LADC patients with higher GAD1 mRNA expression showed significantly poorer prognosis for overall survival in publicly available datasets. Higher immunoreactivity of GAD1 was significantly associated with the pathological stage, pleural invasion, lymph vessel invasion, and poorer prognosis for cancer-specific and disease-free survival. Multivariate analysis revealed that GAD1 protein overexpression is an independent prognosticator for disease-free survival.Conclusions: GAD1 mRNA and protein expression levels were significant prognostic factors in LADC, suggesting that they might be useful biomarkers to stratify patients with worse clinical outcome after resection.
• DOI: info:doi/10.1002/cam4.2345; https://doi.org/info:doi/10.1002/cam4.2345
• Persistent ID (NDL): info:ndljp/pid/11361581; https://dl.ndl.go.jp/pid/11361581
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-10-04T14:36:02+09:00
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/113692
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp