Superabsorbent Polymer Microspheres Prepared with Hypertonic Saline to Reduce Microsphere Expansion. 9

• Material Type: 博士論文
• Title: Superabsorbent Polymer Microspheres Prepared with Hypertonic Saline to Reduce Microsphere Expansion.
• Volume: 41 9
• Author/Editor: Sato, Takeshi; Tanaka, Toshihiro; Nishiofuku, Hideyuki; Fukuoka, Yasushi; Masada, Tetsuya; Tatsumoto, Shota; Marugami, Nagaaki; Morita, Kohei; Obayashi, Chiho; Hori, Shinich; Kaneko, Masaaki; Kijima, Ai; Kichikawa, Kimihiko
• Author Heading: Sato, Takeshi; Tanaka, Toshihiro; Nishiofuku, Hideyuki; Fukuoka, Yasushi; Masada, Tetsuya; Tatsumoto, Shota; Marugami, Nagaaki; Morita, Kohei; Obayashi, Chiho; Hori, Shinich; Kaneko, Masaaki; Kijima, Ai; Kichikawa, Kimihiko
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2018-09; 41 9
• Publication Date (W3CDTF): 2018-09
• Alternative Title: 超吸水性ポリマー球状塞栓物質の高張食塩水を用いた膨潤抑制法の開発
• Periodical title: Cardiovascular and interventional radiology
• Pages: 1412-1418
• ISSN (Periodical Title): 01741551
• Degree Grantor: 奈良県立医科大学
• Date Granted: 2019-06-26
• Date Granted (W3CDTF): 2019-06-26
• Dissertation Number: 甲第709号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第709号
• Text Language Code: eng
• Subject Heading: TACE; Drug-eluting microsphere; Cisplatin
• Target Audience: 一般
• Note (General): type:Thesis; PURPOSE: To analyze size changes of superabsorbent polymer (SAP) microspheres with the reduced expansion technique, and to evaluate pharmacological advantages of transarterial chemoembolization using cisplatin-loaded SAP microspheres with the reduced expansion technique. MATERIALS AND METHODS: In an in vitro study, diluted contrast materials containing different concentrations of sodium ions were examined to expand SAP microspheres and determined the reduced expansion technique. Size distributions of cisplatin-loaded SAP microspheres were analyzed. In an in vivo study, TACE was performed using cisplatin-loaded SAP microspheres with the reduced expansion and control techniques in 18 VX2 rabbits. RESULTS: The degree of expansion was reduced to the greatest extent by using a mixture of non-ionic contrast material and 10% NaCl at a 4:1 ratio. The mean diameter of the reduced expansion of cisplatin-loaded SAP microspheres was 188.4 μm, while that of the control expansion was 404.9 μm. The plasma platinum concentrations of the reduced expansion group at 5 min after TACE were significantly higher than those of the control expansion group (2.19 ± 0.77 vs. 0.75 ± 0.08 μg/mL, P = .01). The tumor platinum concentrations of the reduced expansion group at 1 h were significantly higher than those of the control expansion group (10.76 ± 2.57 vs. 1.57 ± 0.14 μg/g, P = .044). CONCLUSION: The expanding level of SAP microspheres can be reduced by using hypertonic saline. Cisplatin-loaded SAP microspheres with the reduced expansion technique have the advantages of achieving higher cisplatin tissue concentration in TACE for liver tumors.; 博士（医学）・甲第709号・令和元年6月26日; © Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2018; This is a post-peer-review, pre-copyedit version of an article published in Cardiovascular and interventional radiology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00270-018-1990-4.; identifier:Cardiovascular and interventional radiology Vol.41 No.9 p.1412-1418 (2018 Sep); identifier:01741551; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3581; identifier:Cardiovascular and interventional radiology, 41(9): 1412-1418
• Persistent ID (NDL): info:ndljp/pid/11362349; https://dl.ndl.go.jp/pid/11362349
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-10-04T14:36:02+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): https://doi.org/10.1007/s00270-018-1990-4
• Periodical Title (URI): http://hdl.handle.net/10564/3581
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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