Regulatable Transgene Expression for Preventionof Chemotherapy-Induced Peripheral Neuropathy 6 15

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Regulatable Transgene Expression for Preventionof Chemotherapy-Induced Peripheral Neuropathy 15

Persistent ID (NDL): info:ndljp/pid/11378231

Material type: 博士論文

Author: 川田, 大輔

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Publication date: 2017-06

Material Format: Digital

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Name of awarding university/degree: 旭川医科大学,博士（医学）

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Note (General)：: Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating complication associated with drug treatment of cancer for which there are no effec...

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Material Type: 博士論文
Title: Regulatable Transgene Expression for Preventionof Chemotherapy-Induced Peripheral Neuropathy
Volume: 6 15
Author/Editor: 川田, 大輔
Publication Date: 2017-06
Publication Date (W3CDTF): 2017-06
Periodical title: Molecular therapy. Methods and clinical development
Degree grantor/type: 旭川医科大学
Date Granted: 2019-09-30
Date Granted (W3CDTF): 2019-09-30
Dissertation Number: 甲第536号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第536号
Text Language Code: eng
Subject Heading: chemotherapy
intermittent expression
neuroprotective peptides
peripheral neuropathy
therapeutic effect
Note (General): Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating complication associated with drug treatment of cancer for which there are no effective strategies of prevention or treatment. In this study, we examined the effect of intermittent expression of neurotophin-3 (NT-3) or interleukin-10 (IL-10) from replication-defective herpes simplex virus (HSV)-based regulatable vectors delivered by subcutaneous inoculation to the dorsal root ganglion (DRG) on the development of paclitaxel-induced peripheral neuropathy. We constructed two different tetracycline (tet)-on-based regulatable HSV vectors, one expressing NT-3 and the other expressing IL-10, in which the transactivator expression in the tet-on system was under the control of HSV latency-associated promoter 2 (LAP-2), and expression of the transgene was controlled by doxycycline (DOX). We examined the therapeutic effect of intermittent expression of the transgene in animals with paclitaxel-induced peripheral neuropathy modeled by intraperitoneal injection of paclitaxel (16 mg/kg) once a week for 5 weeks. Intermittent expression of either NT-3 or IL-10 3 days before and 1 day after paclitaxel administration protected animals against paclitaxel-induced peripheral neuropathy over the course of 5 weeks. These results suggest the potential of regulatable vectors for prevention of chemotherapy-induced peripheral neuropathy.
identifier:PMID：28702476
開始ページ : 91
終了ページ : 101
DOI: info:doi/10.1016/j.omtm.2017.06.004
https://doi.org/info:doi/10.1016/j.omtm.2017.06.004
Persistent ID (NDL): info:ndljp/pid/11378231
https://dl.ndl.go.jp/pid/11378231
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2019-11-04T14:30:53+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20190930_K536
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp