Oral administration of L-carnitine improves the clinical outcome of fertility in patients with IVF treatment

• Material Type: 博士論文
• Title: Oral administration of L-carnitine improves the clinical outcome of fertility in patients with IVF treatment
• Author/Editor: Kitano, Yuko
• Author Heading: Kitano, Yuko
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2019-03-25
• Publication Date (W3CDTF): 2019-03-25
• Degree grantor/type: 三重大学
• Date Granted: 2019-03-25
• Date Granted (W3CDTF): 2019-03-25
• Dissertation Number: 甲医学第1931号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1931号
• Text Language Code: eng
• Alias of Author: キタノ, ユウコ; 北野, 裕子
• Subject Heading: Fertility treatment; free-fatty acids; mitochondria
• Target Audience: 一般
• Note (General): application/pdf; Age-dependent decline of mitochondrial function has been proposed to be a main cause of decline of embryo quality. Then, L-carnitine plays important roles in reducing the membranous toxicity of free-fatty acids by forming acyl-carnitine and promoting b-oxidation, preventing cell damage. Recent research revealed that L-carnitine played important roles in vitro in oocyte growth, oocyte maturation and embryo development. However, such beneficial effects of L-carnitine in vivo have yet to be verified. The effect of oral L-carnitine supplementation on embryo quality and implantation potential was examined. A total of 214 patients were included in this study. They all previously received in vitro fertilization-embryo transfer (IVF-ET) and failed to conceive. Then they were administered L-carnitine for 82 days on average and underwent IVF-ET again. There were no significant differences in the total number of retrieved oocytes, and their maturation and fertilization rates between before and after L -carnitine administration. The quality of embryos on Days 3 and 5 after insemination was improved following L-carnitine administration (p<.05) in cycles after L-carnitine administration compared with previous cycles. Healthy neonates were born after IVF-ET following L-carnitine administration. Our data suggested that oral administration of L-carnitine to fertility patients improved the developmental competence of their oocytes after insemination.; 本文/Department of Obstetrics and Gynecology, Mie University School of Medicine, Mie, Japan; 6p
• DOI: info:doi/10.1080/09513590.2018.1431769; https://doi.org/info:doi/10.1080/09513590.2018.1431769
• Persistent ID (NDL): info:ndljp/pid/11378277; https://dl.ndl.go.jp/pid/11378277
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-11-04T14:30:53+09:00
• Date Created (W3CDTF): 2019-10-15
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00018399; https://mie-u.repo.nii.ac.jp/records/12780
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-15 再収集