Effect of Sitagliptin on Coronary Flow Reserve Assessed by Magnetic Resonance Imaging in Type 2 Diabetic Patients With Coronary Artery Disease

• Material Type: 博士論文
• Title: Effect of Sitagliptin on Coronary Flow Reserve Assessed by Magnetic Resonance Imaging in Type 2 Diabetic Patients With Coronary Artery Disease
• Author/Editor: Moriwaki, Keishi
• Author Heading: Moriwaki, Keishi
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2019-03-25
• Publication Date (W3CDTF): 2019-03-25
• Degree grantor/type: 三重大学
• Date Granted: 2019-03-25
• Date Granted (W3CDTF): 2019-03-25
• Dissertation Number: 甲医学第1941号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1941号
• Text Language Code: eng
• Alias of Author: モリワキ, ケイシ; 森脇, 啓至
• Subject Heading: Coronary flow reserve; Diabetes mellitus; Dipeptidyl peptidase-4 inhibitor
• Target Audience: 一般
• Note (General): application/pdf; Background: The present study was conducted to assess the cardiovascular effects of dipeptidyl peptidase-4 inhibitors (DPP4i) on coronary flow reserve (CFR), left ventricular (LV) function and endothelial function of the peripheral artery by comparison with those of α-glucosidase inhibitors (αGI) in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD).Methods and Results: We randomly assigned 30 patients with T2DM and CAD to receive either sitagliptin or voglibose, and 28 patients (age 69±9 years, 75% male, hemoglobin A1c [HbA1c] 6.62±0.48%) completed the study (14 in each group). CFR and LV function, assessed by cardiac magnetic resonance imaging, and endothelial function, assessed by reactive hyperemia peripheral arterial tonometry (RH-PAT), were measured at baseline and 24 weeks after treatment. Clinical and laboratory parameters, including HbA1c level, plasma active glucagon-like peptide-1 concentrations, and biomarkers of inflammation, were unchanged in both groups after 24 weeks of treatment. CFR were unchanged in both the αGI group (3.01±0.98 at baseline and 3.06±0.8 after treatment, P=NS) and the DPP4i group (4.29±2.04 at baseline and 3.63±1.31 after treatment, P=NS), with no interaction effect. LV functional parameters and the reactive hyperemia index also remained unchanged after the 24-week treatment.Conclusions: DPP4i did not improve CFR, LV function or endothelial function of the peripheral artery in patients with relativelywell-controlled T2DM and CAD.; 本文/Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan; 9p
• DOI: info:doi/10.1253/circj.CJ-18-0083; https://doi.org/info:doi/10.1253/circj.CJ-18-0083
• Persistent ID (NDL): info:ndljp/pid/11378282; https://dl.ndl.go.jp/pid/11378282
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-11-04T14:30:53+09:00
• Date Created (W3CDTF): 2019-10-16
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00018404; https://mie-u.repo.nii.ac.jp/records/12785
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-15 再収集