Incomplete KLK7 Secretion and Upregulated LEKTI Expression Underlie Hyperkeratotic Stratum Corneum in Atopic Dermatitis. 137 2

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Incomplete KLK7 Secretion and Upregulated LEKTI Expression Underlie Hyperkeratotic Stratum Corneum in Atopic Dermatitis. 2

Persistent ID (NDL): info:ndljp/pid/11378575

Material type: 博士論文

Author: 井川, 哲子

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Publication date: 2017-02

Material Format: Digital

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Name of awarding university/degree: 旭川医科大学,博士（医学）

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Note (General)：: Atopic dermatitis (AD) is a common inflammatory skin disorder. Chronic AD lesions present hyperkeratosis, indicating a disturbed desquamation process....

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Material Type: 博士論文
Title: Incomplete KLK7 Secretion and Upregulated LEKTI Expression Underlie Hyperkeratotic Stratum Corneum in Atopic Dermatitis.
Volume: 137 2
Author/Editor: 井川, 哲子
Publication Date: 2017-02
Publication Date (W3CDTF): 2017-02
Periodical title: The Journal of investigative dermatology
Degree grantor/type: 旭川医科大学
Date Granted: 2016-12-22
Date Granted (W3CDTF): 2016-12-22
Dissertation Number: 甲第503号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第503号
Text Language Code: eng
Note (General): Atopic dermatitis (AD) is a common inflammatory skin disorder. Chronic AD lesions present hyperkeratosis, indicating a disturbed desquamation process. KLK7 is a serine protease involved in the proteolysis of extracellular corneodesmosome components, including desmocollin 1 and corneodesmosin, which leads to desquamation. KLK7 is secreted by lamellar granules and upregulated in AD lesional skin. However, despite increased KLK7 protein levels, immunostaining and electron microscopy indicated numerous corneodesmosomes remaining in the uppermost layer of the stratum corneum from AD lesions. We aimed to clarify the discrepancy between KLK7 overexpression and retention of corneodesmosomes on AD corneocytes. Western blot analysis indicated abnormal corneodesmosin degradation patterns in stratum corneum from AD lesions. The KLK activity of tape-stripped corneocytes from AD lesions was not significantly elevated in in situ zymography, which was our new attempt to detect the protease activity more precisely than conventional assays. This ineffective KLK activation was associated with impaired KLK7 secretion from lamellar granules and increased expression of LEKTI in AD. Such imbalances in protease-protease inhibitor interactions could lead to abnormal proteolysis of corneodesmosomes and compact hyperkeratosis. Upregulated expression of LEKTI might be a compensatory mechanism to prevent further barrier dysfunction in AD.
identifier:PMID:27769847
開始ページ : 449
終了ページ : 456
DOI: info:doi/10.1016/j.jid.2016.10.015
https://doi.org/info:doi/10.1016/j.jid.2016.10.015
Persistent ID (NDL): info:ndljp/pid/11378575
https://dl.ndl.go.jp/pid/11378575
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2019-11-04T14:30:53+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20161222_K503
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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