Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation 1

• Material Type: 博士論文
• ISSN: 2045-2322
• Title: Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation
• Volume: 8 1
• Author/Editor: 池谷, 茂樹
• Author Heading: 池谷, 茂樹
• Publication, Distribution, etc.: Nature Publishing Group
• Publication Date: 2018-03-22
• Publication Date (W3CDTF): 2018-03-22
• Alternative Title: ボリコナゾール誘発性光発がんは芳香族炭化水素受容体依存性COX-2増加により促進される
• Periodical title: Scientific reports
• Degree grantor/type: 浜松医科大学
• Date Granted: 2019-03-08
• Date Granted (W3CDTF): 2019-03-08
• Dissertation Number: 乙第559号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第559号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Voriconazole (VRCZ) induces the development of UV-associated skin cancers. The mechanism underlying the VRCZ-induced carcinogenesis has been largely unknown. Here, we showed that VRCZ metabolites plus UVA generated reactive oxygen species and resultant DNA damage of the epidermis, but did not induce substantial apoptosis in human keratinocytes (KCs). Furthermore, VRCZ per se stimulates aryl hydrocarbon receptor (AhR) and upregulates COX-2, which is a pivotal enzyme for the promotion of UV-associated tumors, in an AhR-ARNT dependent manner of the classical (genomic) pathway. Our findings suggest that the phototoxic moieties of VRCZ metabolites may participate in the initiation phase of VRCZ skin cancer, while VRCZ per se promotes the tumor development. Therefore, during VRCZ therapy, sun exposure protection is essential to prevent photocarcinogenesis caused by VRCZ metabolites plus UV. Chemoprevention with selective COX-2 inhibitors may be helpful to repress the development of skin cancers derived from DNA-damaged KCs.
• DOI: info:doi/10.1038/s41598-018-23439-7; https://doi.org/info:doi/10.1038/s41598-018-23439-7
• Persistent ID (NDL): info:ndljp/pid/11426832; https://dl.ndl.go.jp/pid/11426832
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-01-15T13:48:52+09:00
• Date Created (W3CDTF): 2019-07-23
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003575; https://hama-med.repo.nii.ac.jp/records/3436
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-08 再収集