Talin-2 regulates integrin functions in exosomes

• Material Type: 博士論文
• Title: Talin-2 regulates integrin functions in exosomes
• Author/Editor: Soe, Zay Yar
• Author Heading: Soe, Zay Yar
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2019-09-18
• Publication Date (W3CDTF): 2019-09-18
• Degree grantor/type: 三重大学
• Date Granted: 2019-09-18
• Date Granted (W3CDTF): 2019-09-18
• Dissertation Number: 甲医学第1977号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1977号
• Text Language Code: eng
• Subject Heading: Integrin; Talin; Exosome; Lymphocyte; Cell adhesion; Internalization
• Target Audience: 一般
• Note (General): application/pdf; Integrins on exosomes have been shown to mediate binding to recipient cells, potentially playing important roles in controlling exosomal internalization and organ distributions. Although the ability of cellular integrins to mediate cell adhesion is known to be regulated by the cytoplasmic adaptor protein talin, whether the activity of exosomal integrins is similarly regulated by talin remains to be elucidated. Here we have studied this question in T-cell exosomes that surface express the integrins aLb2 and a4b7. T-cells and T-cell exosomes engineered to lack talin-2 showed reduced binding to the integrin ligand ICAM-1 and MAdCAM-1 compared with control T-cells and exosomes, despite the fact that those T cells and exosomes express intact levels of the other isoform talin-1. In addition, talin-2-deficient T-cell exosomes were less efficiently internalized by endothelial cells, compared with control exosomes. These results suggest that the mechanisms of talin-mediated integrin regulation operate similarly in cells and exosomes.; 本文/Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu, Mie, 514-8507, Japan; 6p
• DOI: info:doi/10.1016/j.bbrc.2019.03.027; https://doi.org/info:doi/10.1016/j.bbrc.2019.03.027
• Persistent ID (NDL): info:ndljp/pid/11429029; https://dl.ndl.go.jp/pid/11429029
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-01-15T13:48:52+09:00
• Date Created (W3CDTF): 2019-12-09
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00018740; https://mie-u.repo.nii.ac.jp/records/13121
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-08 再収集