Tenascin C in colorectal cancer stroma is a predictive marker for liver metastasis and is a potent target of miR-198 as identified by microRNA analysis

• Material Type: 博士論文
• ISSN: 0007-0920
• Title: Tenascin C in colorectal cancer stroma is a predictive marker for liver metastasis and is a potent target of miR-198 as identified by microRNA analysis
• Volume: 117 9
• Author/Editor: 村上, 智洋
• Author Heading: 村上, 智洋
• Publication, Distribution, etc.: Nature Publishing Group on behalf of Cancer Research UK
• Publication Date: 2017-10-24
• Publication Date (W3CDTF): 2017-10-24
• Alternative Title: 大腸がん間質のTenascin Cは肝転移の予測マーカーであり、microRNA解析から同定されたmiR-198の潜在的な標的遺伝子である
• Periodical title: British journal of cancer
• Degree grantor/type: 浜松医科大学
• Date Granted: 2019-03-13
• Date Granted (W3CDTF): 2019-03-13
• Dissertation Number: 甲第803号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第803号
• Text Language Code: eng
• Subject Heading: colorectal cancer; liver metastasis; tumour stroma; prognostic markers; microRNA; tenascin C; miR-198
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Background: Tumour stroma has important roles in the development of colorectal cancer (CRC) metastasis. We aimed to clarify the roles of microRNAs (miRNAs) and their target genes in CRC stroma in the development of liver metastasis.Methods: Tumour stroma was isolated from formalin-fixed, paraffin-embedded tissues of primary CRCs with or without liver metastasis by laser capture microdissection, and miRNA expression was analysed using TaqMan miRNA arrays. Results: Hierarchical clustering classified 16 CRCs into two groups according to the existence of synchronous liver metastasis. Combinatory target prediction identified tenascin C as a predicted target of miR-198, one of the top 10 miRNAs downregulated in tumour stroma of CRCs with synchronous liver metastasis. Immunohistochemical analysis of tenascin C in 139 primary CRCs revealed that a high staining intensity was correlated with synchronous liver metastasis (P<0.001). Univariate and multivariate analyses revealed that the tenascin C staining intensity was an independent prognostic factor to predict postoperative overall survival (P=0.005; n=139) and liver metastasis-free survival (P=0.001; n=128).Conclusions: Alterations of miRNAs in CRC stroma appear to form a metastasis-permissive environment that can elevate tenascin C to promote liver metastasis. Tenascin C in primary CRC stroma has the potential to be a novel biomarker to predict postoperative prognosis.
• DOI: info:doi/10.1038/bjc.2017.291; https://doi.org/info:doi/10.1038/bjc.2017.291
• Persistent ID (NDL): info:ndljp/pid/11429076; https://dl.ndl.go.jp/pid/11429076
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-01-15T13:48:52+09:00
• Date Created (W3CDTF): 2019-12-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003667; https://hama-med.repo.nii.ac.jp/records/3530
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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