Lysophosphatidic acid precursor levels decrease and an arachidonic acid-containing phosphatidylcholine level increases in the dorsal root ganglion of mice after peripheral nerve injury

• Material Type: 博士論文
• ISSN: 0304-3940
• Title: Lysophosphatidic acid precursor levels decrease and an arachidonic acid-containing phosphatidylcholine level increases in the dorsal root ganglion of mice after peripheral nerve injury
• Volume: 698
• Author/Editor: 三原, 唯暉
• Author Heading: 三原, 唯暉
• Publication, Distribution, etc.: Elsevier Scientific Publishers Ireland
• Publication Date: 2019-04-17
• Publication Date (W3CDTF): 2019-04-17
• Alternative Title: 末梢神経損傷後のマウス後根神経節においてリゾホスファチジン酸の前駆体は減少し、アラキドン酸含有リン脂質は増加する
• Periodical title: Neuroscience letters
• Degree grantor/type: 浜松医科大学
• Date Granted: 2019-03-13
• Date Granted (W3CDTF): 2019-03-13
• Dissertation Number: 甲第811号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第811号
• Text Language Code: eng
• Subject Heading: Peripheral nerve injury; Neuropathic pain; Lysophosphatidic acid; Sciatic nerve transection; Matrix-assisted laser desorption ionization; Imaging mass spectrometry
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; In the current study, we aimed to analyze the lipid changes in the dorsal root ganglion (DRG) after sciatic nerve transection (SNT) using matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS). We found that the arachidonic acid-containing phosphatidylcholine (AA-PC), PC(16:0/20:4) largely increased, while PC(16:0/18:1), PC(18:0/18:1) and phosphatidic acid (PA)(36:2) levels largely decreased in the DRG following nerve injury. Previous studies show that the increase in PC(16:0/20:4) was associated with neuropathic pain and that decrease in PC(16:0/18:1), PC(18:0/18:1), and PA(36:2) were due to producing lysophosphatidic acid (LPA), an initiator for neuropathic pain. These results suggest that the lipid changes in DRG after SNT could be the result of changes for the cause of neuropathic pain. Thus, blocking of LPA could be potential for treatment of neuropathic pain.
• DOI: info:doi/10.1016/j.neulet.2018.12.035; https://doi.org/info:doi/10.1016/j.neulet.2018.12.035
• Persistent ID (NDL): info:ndljp/pid/11429079; https://dl.ndl.go.jp/pid/11429079
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-01-15T13:48:52+09:00
• Date Created (W3CDTF): 2019-12-06
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003671; https://hama-med.repo.nii.ac.jp/records/3534
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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