Symptomatic Characteristics of Parkinson's Disease Induced by Neuroleptic Drugs,Based on a Functional Neuroimaging Diagnosis

• Material Type: 博士論文
• Title: Symptomatic Characteristics of Parkinson's Disease Induced by Neuroleptic Drugs,Based on a Functional Neuroimaging Diagnosis
• Author/Editor: Tachibana, Kei
• Author Heading: Tachibana, Kei
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2019-12-18
• Publication Date (W3CDTF): 2019-12-18
• Degree grantor/type: 三重大学
• Date Granted: 2019-12-18
• Date Granted (W3CDTF): 2019-12-18
• Dissertation Number: 甲医学第1996号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1996号
• Text Language Code: eng
• Alias of Author: タチバナ, ケイ; 橘, 径
• Subject Heading: Parkinson disease; drug induced parkinsonism; asymmetric; autonomic dysfunction; tremor; dopamine transporter single-photon emission computed tomography
• Target Audience: 一般
• Note (General): application/pdf; Objective: When patients take neuroleptics, the distinction between Parkinson’s disease (PD) and drug-induced parkinsonism (DIP) based solely on clinical features can become difficult. At present, 123I-FP-CIT SPECT (DAT-SPECT) and 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy are widely used to supplement the differential diagnosis of parkinsonism. This study assessed the clinical symptoms and neurological findings in the patients suspected of having DIP based on DAT-SPECT findings.Methods and Patients: Twenty-three patients (11 men, 12 women, age: 52-81 years old) presenting with DIP were recruited. All patients underwent neurological examinations, including brain magnetic resonance imaging and DAT-SPECT. Patients who showed abnormal DAT-SPECT results underwent MIBG myocardial scintigraphy.Results: Eleven patients showed a reduction in the ligand uptake on DAT-SPECT (DAT-positive group), and nine of these patients showed a low delayed heart-to-mediastinum (H/M) ratio on MIBG myocardial scintigraphy. The remaining 12 patients showed normal results on DAT-SPECT (DAT-negative group). All patients in the DAT-positive group had asymmetric motor symptoms, whereas only 4 in the DAT-negative group exhibited this clinical feature (p=0.001). A detailed medical history showed that 7 of the 11 patients in the DAT-positive group had prodromal symptoms for PD. However, only 1 patient in the DAT-negative group exhibited these symptoms (p= 0.009). Although two patients in the DAT-negative group showed poor improvement, they showed a normal H/M ratio on MIBG and no response to levodopa. Conclusion: The patients in the DAT-positive group might have prodromal symptoms that were worsened by neuroleptic drugs. The results of detailed history-taking and neurological findings seem to indicate cases of compromised dopaminergic transmission before the administration of neuroleptic drugs.; 本文/Department of Neurology, Mie University Graduate School of Medicine, Tsu, Mie, Japan; 25p
• Persistent ID (NDL): info:ndljp/pid/11449759; https://dl.ndl.go.jp/pid/11449759
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-02-10T02:20:18+09:00
• Date Created (W3CDTF): 2020-02-04
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00018954; https://mie-u.repo.nii.ac.jp/records/13335
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-08 再収集