Immunohistochemical expression and clinicopathological assessment of the cancer testis antigens NY‑ESO‑1 and MAGE‑A4 in high‑grade soft‑tissue sarcoma

• Material Type: 博士論文
• Title: Immunohistochemical expression and clinicopathological assessment of the cancer testis antigens NY‑ESO‑1 and MAGE‑A4 in high‑grade soft‑tissue sarcoma
• Author/Editor: KAKIMOTO, TAKUYA
• Author Heading: KAKIMOTO, TAKUYA
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2019-12-18
• Publication Date (W3CDTF): 2019-12-18
• Degree grantor/type: 三重大学
• Date Granted: 2019-12-18
• Date Granted (W3CDTF): 2019-12-18
• Dissertation Number: 乙医学第1046号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 乙医学第1046号
• Text Language Code: eng
• Alias of Author: カキモト, タクヤ; 柿本, 拓也
• Subject Heading: New York‑esophageal squamous cell carcinoma‑1; melanoma‑associated antigen‑4; high grade soft tissue sarcoma; cancer testis antigens; synovial sarcoma
• Target Audience: 一般
• Note (General): application/pdf; The aim of the present study was to explore the expression of the cancer testis antigens New York‑esophageal squamous cell carcinoma (NY‑ESO) ‑1 and melanoma‑associated antigen (MAGE)‑A4 in high‑grade soft‑tissue sarcoma and to evaluate their association with the standard clinical‑pathological features of surgically treated high‑grade sarcoma patients. The study included 82 patients, and NY‑ESO‑1 and MAGE‑A4 antigen expression was analyzed immunohistochemically. The results revealed NY‑ESO‑1‑ and MAGE‑A4‑positive staining in 58.8 and 52.9% of synovial sarcomas, and 55.6 and 0% of myxoid liposarcomas, respectively. In patients with synovial sarcoma, NY‑ESO‑1 and MAGE‑A4 were expressed in 7 patients, onlyNY‑ESO‑1 was expressed in 3 patients, and only MAGE‑A4was expressed in 2 patients. Univariate analysis indicated that a significantly higher MAGE‑A4 expression was observed in younger patients (P<0.001) and those with synovial sarcoma(P<0.001). Multivariate analysis indicated that significantly higher NY‑ESO‑1 expression was observed in patients with synovial sarcoma (P<0.01) and myxoid liposarcoma(P<0.01), and significantly higher MAGE‑A4 expression was observed in patients with synovial sarcoma (P<0.01). In high‑grade sarcomas, the 2‑ and 5‑year overall survival rates based on Kaplan‑Meier estimates were 100 and 81.3% in the NY‑ESO‑1‑positive group, and 69.7 and 53.0% in the NY‑ESO‑1‑negative group, respectively (P=0.049). It was also demonstrated that either NY‑ESO‑1 or MAGE‑A4 was positive in 70.6% of synovial sarcomas. These results indicate that NY‑ESO‑1 and MAGE‑A4 may be useful for the diagnosis of synovial sarcoma. The independent expression of NY‑ESO‑1and MAGE‑A4, which may help expand the pool of candidates for molecular‑targeted immunotherapy, will be beneficial for synovial sarcoma patients.; 本文/Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Mie 514‑8507; 7p
• DOI: info:doi/10.3892/ol.2019.10044; https://doi.org/info:doi/10.3892/ol.2019.10044
• Persistent ID (NDL): info:ndljp/pid/11449760; https://dl.ndl.go.jp/pid/11449760
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-02-10T02:20:18+09:00
• Date Created (W3CDTF): 2020-02-04
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00018955; https://mie-u.repo.nii.ac.jp/records/13336
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-09 再収集