Regulation of α-klotho Expression by Dietary Phosphate During Growth Periods

• Material Type: 博士論文
• ISSN: 0171-967X
• Title: Regulation of α-klotho Expression by Dietary Phosphate During Growth Periods
• Volume: 104 6
• Author/Editor: Fukuda-Tatano, Shiori; Yamamoto, Hironori; Nakahashi, Otoki; Yoshikawa, Ryouhei; Hayashi, Mayu; Kishimoto, Maki; Imi, Yukiko; Yamanaka-Okumura, Hisami; Ohnishi, Kohta; Masuda, Masashi; Taketani, Yutaka
• Author Heading: Fukuda-Tatano, Shiori; Yamamoto, Hironori; Nakahashi, Otoki; Yoshikawa, Ryouhei; Hayashi, Mayu; Kishimoto, Maki; Imi, Yukiko; Yamanaka-Okumura, Hisami; Ohnishi, Kohta; Masuda, Masashi; Taketani, Yutaka
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2019-01-23
• Publication Date (W3CDTF): 2019-01-23
• Alternative Title: 成長期における食餌性リンによるα-klotho発現制御
• Periodical title: Calcified Tissue International
• Degree grantor/type: 徳島大学
• Date Granted: 2019-03-22
• Date Granted (W3CDTF): 2019-03-22
• Dissertation Number: 甲第3278号
• Degree Type: 博士（栄養学）
• Conferring No. (Dissertation): 甲第3278号
• Text Language Code: eng
• Subject Heading: Dietary phosphate; Growth periods; α-Klotho; FGF23; Vitamin D metabolism; Kidney
• Target Audience: 一般
• Note (General): Inorganic phosphate (Pi) is an essential nutrient for maintaining various biological functions, particularly during growth periods. Excess intake of dietary Pi increases the secretion of fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) to maintain plasma Pi levels. FGF23 is a potent phosphaturic factor that binds to the α-klotho/FGFR complex in the kidney to promote excretion of Pi into the urine. In addition, excess intake of dietary Pi decreases renal α-klotho expression. Down-regulation or lack of α-klotho induces a premature aging-like phenotype, resulting from hyperphosphatemia, and leading to conditions such as ectopic calcification and osteoporosis. However, it remains unclear what effects dietary Pi has on α-klotho expression at different life stages, especially during growth periods. To investigate this, we used C57BL/6J mice in two life stages during growing period. Weaned (3 weeks old) and periadolescent (7 weeks old) were randomly divided into seven experimental groups and fed with 0.02, 0.3, 0.6, 0.9, 1.2, 1.5, or 1.8% Pi diets for 7 days. As a result, elevated plasma Pi and FGF23 levels and decreased renal α-klotho expression were observed in weaned mice fed with a high Pi diet. In addition, a high Pi diet clearly induced renal calcification in the weaned mice. However, in the periadolescent group, renal calcification was not observed, even in the 1.8% Pi diet group. The present study indicates that a high Pi diet in weaned mice has much greater adverse effects on renal α-klotho expression and pathogenesis of renal calcification compared with periadolescent mice.
• DOI: info:doi/10.1007/s00223-019-00525-0; https://doi.org/info:doi/10.1007/s00223-019-00525-0
• Persistent ID (NDL): info:ndljp/pid/11458128; https://dl.ndl.go.jp/pid/11458128
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-03-11T23:38:06+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/113367
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp