Imaging mass spectrometry reveals sodium lauryl sulfate-induced changes in skin lipoquality, principally affecting sphingomyelin 1

• Material Type: 博士論文
• Title: Imaging mass spectrometry reveals sodium lauryl sulfate-induced changes in skin lipoquality, principally affecting sphingomyelin
• Volume: 3 1
• Author/Editor: 齋藤, 祐介
• Author Heading: 齋藤, 祐介
• Publication Date: 2019
• Publication Date (W3CDTF): 2019
• Alternative Title: 質量顕微鏡法によるスフィンゴミエリンに影響を与えるラウリル硫酸ナトリウム誘発性の皮膚脂質の変化の解明
• Periodical title: Medical Mass Spectrometry
• Degree grantor/type: 浜松医科大学
• Date Granted: 2019-05-17
• Date Granted (W3CDTF): 2019-05-17
• Dissertation Number: 乙第562号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第562号
• Text Language Code: eng
• Subject Heading: Skin; Pharmaceuticals; Matrix-assisted laser desorption/ionization-imaging mass spectrometry (MALDI-IMS); Sodium lauryl sulfate; Lipids
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Lipids and lipoqualities are important for skin barrier function. In previous reports, repeated irritation by sodium lauryl sulfate (SLS) was found to reduce epidermal barrier function and epidermal water content. Imaging mass spectrometry (IMS) can reveal not only the identity and localization of lipids in organs but also the distribution of administered drugs. Here, we attempted to visualize the distribution of SLS and changes in lipid composition in the epidermis of the skin. Initially, we histologically examined micro damage of the skin using trypan blue in the foot-pad of mice treated with SLS. Subsequently, we assessed the invasion of SLS and the effect of SLS on the lipid composition of the skin using IMS. We found that, relative to the foot-pad of mice treated with saline, the foot-pad of mice treated with SLS exhibited a significant change in m/z 817.71 associated with sphingomyelin despite the fact that no noticeable damage was observed in the layer structure dyed with trypan blue. Furthermore, we proved the penetration of SLS to the epidermis and dermis. The results suggest that SLS penetrates the skin tissue and alters the lipid composition on the skin surface.
• Persistent ID (NDL): info:ndljp/pid/11458381; https://dl.ndl.go.jp/pid/11458381
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-03-11T23:38:06+09:00
• Date Created (W3CDTF): 2020-02-25
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003679; https://hama-med.repo.nii.ac.jp/records/3542
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-09 再収集