Cisplatin-induced programmed cell death ligand-2 expression is associated with metastasis ability in oral squamous cell carcinoma.

• Material Type: 博士論文
• Title: Cisplatin-induced programmed cell death ligand-2 expression is associated with metastasis ability in oral squamous cell carcinoma.
• Author/Editor: Sudo, Shunichi; Kajiya, Hiroshi; Okano, Shinji; Sasaki, Mina; Katsumata, Yuri; Ohno, Jun; Ikebe, Tetsuro; Hiraki, Akimitsu; Okabe, Koji
• Publication Date: 2020-03-14
• Publication Date (W3CDTF): 2020-03-14
• Alternative Title: Cisplatin-induced programmed cell death ligand-2 expression is associated with metastasis ability in oral squamous cell carcinoma.
• Degree grantor/type: 福岡歯科大学
• Date Granted: 2020-03-14
• Date Granted (W3CDTF): 2020-03-14
• Dissertation Number: 甲第318号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第318号
• Text Language Code: eng
• Subject Heading: cisplatin; metastasis; oral squamous cell carcinoma; programmed cell death ligand 2; signal transducers and activator of transcription 1/3
• Note (General): Programmed cell death ligands (PD-Ls) are expressed in tumor cells where they bind to programmed cell death-1, an immunocyte co-receptor, resulting in tumor cell evasion from the immune system. Chemotherapeutic drugs have been recently reported to induce the expression of PD-L, such as PD-L1, in some cancer cells. However, little is known regarding PD-L2 expression and its role in oral squamous cell carcinoma (OSCC). In this study, we examined the effect of cisplatin on the expression and regulation of PD-L2 in OSCC cell lines and analyzed malignant behavior in PD-L2-expressing cells using colony, transwell and transformation assays. In addition, we examined PD-L2 expression in the tumor tissues of OSCC patients using cytology and tissue microarray methods. In OSCC cell lines, cisplatin treatment upregulated PD-L2 expression, along with that of the drug efflux transporter ABCG2, via signal transducers and activator of transcription (STAT) 1/3 activation. Moreover, PD-L2-positive or PD-L2-overexpressing cells demonstrated upregulation in both invasion and transformation ability but not in proliferation compared with PD-L2-negative or PD-L2-silencing cells. PD-L2 expression was also observed in OSCC cells of cytology samples and tissue from OSCC patients. The intensity of PD-L2 expression was correlated with more malignant morphological features in the histological appearance and an invasive pattern. Our findings indicate that cisplatin-upregulated PD-L2 expression in OSCC via STAT1/3 activation and the expression of PD-L2 are likely to be associated with malignancy in OSCC. The PD-L2 expression in cisplatin-resistant OSCC cells may be a critical factor in prognosis of advanced OSCC patients.; 2019年度; 元資料の権利情報 : CC BY-NC-ND
• Persistent ID (NDL): info:ndljp/pid/11479226; https://dl.ndl.go.jp/pid/11479226
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-04-06T03:04:11+09:00
• Date Created (W3CDTF): 2020-03-25
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Original Material (URI): https://doi.org/10.1111/cas.14336
• Periodical Title (URI): http://id.nii.ac.jp/1167/00000092/
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp