Increased presepsin levels are associated with the severity of fungal bloodstream infections

• Material Type: 博士論文
• Title: Increased presepsin levels are associated with the severity of fungal bloodstream infections
• Author/Editor: Bamba, Yuuki
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2019-03-25
• Publication Date (W3CDTF): 2019-03-25
• Alternative Title: Increased presepsin levels are associated with the severity of fungal bloodstream infections; 真菌血流感染症においてプレセプシンの増加は重症度と関連する
• Degree grantor/type: 新潟大学
• Date Granted: 2019-03-25
• Date Granted (W3CDTF): 2019-03-25
• Dissertation Number: 甲第4559号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4559号
• Text Language Code: eng
• Note (General): BackgroundPresepsin is a widely recognized biomarker for sepsis. However, little is known about the usefulness of presepsin in invasive fungal infection. The aim of this study was to determine the plasma levels of presepsin in fungal bloodstream infections and to investigate whether it reflects the disease severity, similar to its utility in bacterial infections.MethodsWe prospectively measured presepsin in plasma samples from participants with fungemia from April 2016 to December 2017. The associations of C-reactive protein, procalcitonin, and presepsin concentrations with the severity of fungemia were statistically analyzed. In vitro assay was performed by incubating Escherichia coli, Candida albicans, and lipopolysaccharide to whole blood cells collected from healthy subjects; after 3 h, the presepsin concentration was measured in the supernatant and was compared among the bacteria, fungi, and LPS groups.ResultsPresepsin was increased in 11 patients with fungal bloodstream infections. Serial measurement of presepsin levels demonstrated a prompt decrease in 7 patients in whom treatment was effective, but no decrease or further increase in the patients with poor improvement. Additionally, presepsin concentrations were significantly correlated with the Sequential Organ Failure Assessment score (r = 0.89, p < 0.001). In vitro assay with co-incubation of C. albicans and human whole blood cells indicated that the viable cells of C. albicans caused an increase in presepsin, as seen with E. coli.ConclusionsPlasma presepsin levels increased in patients with fungal bloodstream infection, with positive association with the disease severity. Presepsin could be a useful biomarker of sepsis secondary to fungal infections.; 学位の種類: 博士（医学）. 報告番号: 甲第4559号. 学位記番号: 新大院博（医）甲第881号. 学位授与年月日: 平成31年3月25日; 新大院博（医）甲第881号; 元資料の権利情報 : 【○!C】2018 Bamba et al.
• Persistent ID (NDL): info:ndljp/pid/11498331; https://dl.ndl.go.jp/pid/11498331
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• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-06-07T00:39:19+09:00
• Date Created (W3CDTF): 2019-09-10
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Periodical Title (URI): http://hdl.handle.net/10191/51308
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp