Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia

• Material Type: 博士論文
• Title: Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia
• Author/Editor: Yukawa, Takayuki
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2019-03-25
• Publication Date (W3CDTF): 2019-03-25
• Alternative Title: Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia; 統合失調症患者死後脳海馬におけるコンドロイチン硫酸部位の病理学的変化
• Degree grantor/type: 新潟大学
• Date Granted: 2019-03-25
• Date Granted (W3CDTF): 2019-03-25
• Dissertation Number: 甲第4536号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4536号
• Text Language Code: eng
• Note (General): Perineuronal nets comprise chondroitin sulfate moieties and their core proteins, and their neuropathological alterations have been implicated in schizophrenia. To explore the molecular mechanism of the perineuronal net impairments in schizophrenia, we measured the immunoreactivity of chondroitin sulfate moieties, major components of perineuronal nets, in three brain regions (postmortem dorsolateral prefrontal cortex, caudate nucleus, and hippocampus) of schizophrenia patients and control subjects. Immunoblotting for chondroitin 4-sulfate and chondroitin 6-sulfate moieties revealed a significant increase in intensity of a 180 kD band of chondroitin 4- sulfate immunoreactivity in the hippocampus of patients, although we detected no significant alteration in their immunoreactivities with any other molecular sizes or in other brain regions. The levels of immunoreactivity were not correlated with postmortem interval, age, or storage time. We failed to find such an increase in a similar molecular range of the chondroitin 4-sulfate immunoreactivity in the hippocampus of the rats chronically treated with haloperidol. These results suggest that the level alteration of the chondroitin 4-sulfate moiety might contribute to the perineuronal net abnormality found in patients with schizophrenia.; 学位の種類: 博士（医学）. 報告番号: 甲第4536号. 学位記番号: 新大院博（医）甲第858号. 学位授与年月日: 平成31年3月25日; 新大院博（医）甲第858号; 元資料の権利情報 : 【○!C】2018 Elsevier B.V. All rights reserved.
• Persistent ID (NDL): info:ndljp/pid/11498338; https://dl.ndl.go.jp/pid/11498338
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-06-07T00:39:19+09:00
• Date Created (W3CDTF): 2019-09-10
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/51317
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp