Caffeic Acid Phenethyl Ester (CAPE) Induces VEGF Expression and Production in Rat Odontoblastic Cells

• Material Type: 博士論文
• ISSN: 2314-6133
• Title: Caffeic Acid Phenethyl Ester (CAPE) Induces VEGF Expression and Production in Rat Odontoblastic Cells
• Volume: 2019
• Author/Editor: Kuramoto, Hitomi; Hirao, Kouji; Yumoto, Hiromichi; Hosokawa, Yuki; Nakanishi, Tadashi; Takegawa, Daisuke; Washio, Ayako; Kitamura, Chiaki; Matsuo, Takashi
• Author Heading: Kuramoto, Hitomi; Hirao, Kouji; Yumoto, Hiromichi; Hosokawa, Yuki; Nakanishi, Tadashi; Takegawa, Daisuke; Washio, Ayako; Kitamura, Chiaki; Matsuo, Takashi
• Publication, Distribution, etc.: Hindawi
• Publication Date: 2019-12-21
• Publication Date (W3CDTF): 2019-12-21
• Alternative Title: カフェイン酸フェネチルエステル（CAPE）がラット象牙芽細胞様細胞のVEGF発現と産生に与える影響
• Periodical title: BioMed Research International
• Degree grantor/type: 徳島大学
• Date Granted: 2020-03-23
• Date Granted (W3CDTF): 2020-03-23
• Dissertation Number: 甲第3376号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第3376号
• Text Language Code: eng
• Subject Heading: Caffeic acid phenethyl ester (CAPE); VEGF; odontoblast; KN-3
• Target Audience: 一般
• Note (General): Caffeic acid phenethyl ester (CAPE), the main component of propolis, has various biological activities including anti-inflammatory effect and wound healing promotion. Odontoblasts located in the outermost layer of dental pulp play crucial roles such as production of growth factors and formation of hard tissue termed reparative dentin in host defense against dental caries. In this study, we investigated the effects of CAPE on the upregulation of vascular endothelial growth factor (VEGF) and calcification activities of odontoblasts, leading to development of novel therapy for dental pulp inflammation caused by dental caries. CAPE significantly induced mRNA expression and production of VEGF in rat clonal odontoblast-like KN-3 cells cultured in normal medium or osteogenic induction medium. CAPE treatment enhanced nuclear factor-kappa B (NF-κB) transcription factor activation, and furthermore, the specific inhibitor of NF-κB significantly reduced VEGF production. The expression of VEGF receptor- (VEGFR-) 2, not VEGFR-1, was up regulated in KN-3 cells treated with CAPE. In addition, VEGF significantly increased mineralization activity in KN-3 cells. These findings suggest that CAPE might be useful as a novel biological material for the dental pulp conservative therapy.
• DOI: info:doi/10.1155/2019/5390720; https://doi.org/info:doi/10.1155/2019/5390720
• Persistent ID (NDL): info:ndljp/pid/11498390; https://dl.ndl.go.jp/pid/11498390
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-06-07T00:39:19+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/114566
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp