Effect of prenatal administration of low dose antibiotics on gut microbiota and body fat composition of newborn mice

Persistent ID (NDL): info:ndljp/pid/11498406

Material type: 博士論文

Author: Yoshimoto, Ayumiほか

Publisher: Society for Free Radical Research Japan

Publication date: 2018-03-01

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 徳島大学,博士（栄養学）

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Note (General)：: Several environmental factors during the prenatal period transgenerationally affect the health of newborns in later life. Because low-dose antibiotics...

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Digital

Material Type: 博士論文
ISSN: 0912-0009
Title: Effect of prenatal administration of low dose antibiotics on gut microbiota and body fat composition of newborn mice
Volume: 62 2
Author/Editor: Yoshimoto, Ayumi
Uebanso, Takashi
Nakahashi, Mutsumi
Shimohata, Takaaki
Mawatari, Kazuaki
Takahashi, Akira
Author Heading: Yoshimoto, Ayumi
Uebanso, Takashi
Nakahashi, Mutsumi
Shimohata, Takaaki
Mawatari, Kazuaki
Takahashi, Akira
Publication, Distribution, etc.: Society for Free Radical Research Japan
Publication Date: 2018-03-01
Publication Date (W3CDTF): 2018-03-01
Alternative Title: 胎生期の低用量抗菌薬摂取が、子の腸内細菌叢や体脂肪組成に及ぼす影響
Periodical title: Journal of Clinical Biochemistry and Nutrition
Degree grantor/type: 徳島大学
Date Granted: 2020-03-23
Date Granted (W3CDTF): 2020-03-23
Dissertation Number: 甲第3416号
Degree Type: 博士（栄養学）
Conferring No. (Dissertation): 甲第3416号
Text Language Code: eng
Subject Heading: CE-MS
DGGE
adiposity
maternal
transgenerational
Target Audience: 一般
Note (General): Several environmental factors during the prenatal period transgenerationally affect the health of newborns in later life. Because low-dose antibiotics have been used for promoting the growth of crops and livestock in agriculture, humans may have ingested residual antibiotics for several decades. However, the effect of prenatal administration of low-dose antibiotics on newborns’ health in later life is unclear. In the present study, we found that prenatal treatment of murine mothers with low-dose antibiotics increased the abundance of bacteria of the phylum Firmicutes and the genera Clostridium IV and XIVa in feces from pups. In addition, the body fat percentage of mice in the antibiotic-treated group was higher than those in the control group at 12 weeks of age even though all pups were fed a standard diet. The body fat percentage of all mice was correlated with the abundance of fecal bacteria of Clostridium IV and XIVa. These results predict that low-dose antibiotic administration during the prenatal period affects the gut microbiota of newborns and possibly their health in later life.
DOI: info:doi/10.3164/jcbn.17-53
https://doi.org/info:doi/10.3164/jcbn.17-53
Persistent ID (NDL): info:ndljp/pid/11498406
https://dl.ndl.go.jp/pid/11498406
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2020-06-07T00:39:19+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/114647
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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