Plasma substance P concentrations in patients undergoing general anesthesia : an objective marker associated with postoperative nausea and vomiting

Persistent ID (NDL): info:ndljp/pid/11498498

Material type: 博士論文

Author: 池﨑, 尚子ほか

Publisher: Japanese Society of Anesthesiologists|Springer Nature

Publication date: 2016-06-02

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（医学）

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Note (General)：: Background: This study investigated plasma concentrations of substance P (SP) in patients undergoing general anesthesia (GA) and postoperative nausea ...

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Material Type: 博士論文
ISSN: 2363-9024
Title: Plasma substance P concentrations in patients undergoing general anesthesia : an objective marker associated with postoperative nausea and vomiting
Volume: 2
Author/Editor: 池﨑, 尚子
Kakuta, Nami
Horikawa, Yousuke T.
Tsutsumi, Rie
Oyama, Takuro
Tanaka, Katsuya
Tsutsumi, Yasuo M.
Author Heading: 池﨑, 尚子
Kakuta, Nami
Horikawa, Yousuke T.
Tsutsumi, Rie
Oyama, Takuro
Tanaka, Katsuya
Tsutsumi, Yasuo M.
Publication, Distribution, etc.: Japanese Society of Anesthesiologists|Springer Nature
Publication Date: 2016-06-02
Publication Date (W3CDTF): 2016-06-02
Alternative Title: 全身麻酔下の患者の血漿サブスタンスP濃度 : 術後嘔気・嘔吐の有用な指標となる
Periodical title: JA Clinical Reports
Degree grantor/type: 徳島大学
Date Granted: 2020-04-23
Date Granted (W3CDTF): 2020-04-23
Dissertation Number: 甲第3425号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第3425号
Text Language Code: eng
Subject Heading: General anesthesia
Plasma substance P
PONV
Substance P
Target Audience: 一般
Note (General): Background: This study investigated plasma concentrations of substance P (SP) in patients undergoing general anesthesia (GA) and postoperative nausea and vomiting (PONV). This prospective, observational, cohort study included 23 patients who underwent scheduled surgery under general anesthesia. Blood was collected from the radial artery at predetermined time points (15–30 mins prior anesthesia, 15–30 mins after surgery/GA, and 24 h after surgery). PONV, SP concentrations, risk factors, and analgesics used were measured.Findings: Nine of 23 patients experienced PONV. In patients without PONV, SP concentrations significantly decreased (P < 0.0001) at the end of surgery/GA, compared to baseline, and recovered at 24 h after surgery/GA (452.9 ± 146.2 vs. 666.9 ± 176.5 vs. 580.7 ± 168.6 pg/mL, respectively), whereas SP levels were unchanged during surgery/GA and increased at 24 hours after surgery (P = 0.020) in patients with PONV (726.1 ± 167.8 vs. 655.8 ± 168.0 vs. 779.7 ± 220.7 pg/mL, respectively).Conclusions: These finding suggest that SP levels may be utilized as an objective marker for PONV.
DOI: info:doi/10.1186/s40981-016-0034-9
https://doi.org/info:doi/10.1186/s40981-016-0034-9
Persistent ID (NDL): info:ndljp/pid/11498498
https://dl.ndl.go.jp/pid/11498498
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2020-06-07T00:39:19+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/114557
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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