Circulating Apolipoprotein L1 is associated with insulin resistance-induced abnormal lipid metabolism

• Material Type: 博士論文
• ISSN: 2045-2322
• Title: Circulating Apolipoprotein L1 is associated with insulin resistance-induced abnormal lipid metabolism
• Volume: 9
• Author/Editor: Nishimura, Kenji; Murakami, Taichi; Sakurai, Toshihiro; Miyoshi, Masashi; Kurahashi, Kiyoe; Kishi, Seiji; Tamaki, Masanori; Tominaga, Tatsuya; Yoshida, Sumiko; Nagai, Kojiro; Abe, Hideharu; Hui, Shu-Ping; Kotani, Kazuhiko; Doi, Toshio
• Author Heading: Nishimura, Kenji; Murakami, Taichi; Sakurai, Toshihiro; Miyoshi, Masashi; Kurahashi, Kiyoe; Kishi, Seiji; Tamaki, Masanori; Tominaga, Tatsuya; Yoshida, Sumiko; Nagai, Kojiro; Abe, Hideharu; Hui, Shu-Ping; Kotani, Kazuhiko; Doi, Toshio
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2019-10-16
• Publication Date (W3CDTF): 2019-10-16
• Alternative Title: 循環アポリポプロテインL1はインスリン抵抗性が引き起こす脂質代謝異常に関連する
• Periodical title: Scientific Reports
• Degree grantor/type: 徳島大学
• Date Granted: 2020-03-23
• Date Granted (W3CDTF): 2020-03-23
• Dissertation Number: 甲第3361号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3361号
• Text Language Code: eng
• Subject Heading: Apolipoprotein L1; ApoL1; insulin resistance; abnormal lipid metabolism; insulin
• Target Audience: 一般
• Note (General): Circulating ApolipoproteinL1 (ApoL1) is a component of pre-β-high-density lipoprotein (HDL), however little is known about the relationship of ApoL1 with cardiometabolic factors. Considering previous studies reporting the correlation of ApoL1 to triglyceride, we have hypothesized that ApoL1 associates with insulin-related metabolism. The current study examined their associations in 126 non-diabetic subjects and 36 patients with type 2 diabetes (T2DM). Non-diabetic subjects demonstrated triglyceride (standardized coefficients [s.c.] = 0.204, p < 0.05), body mass index (s.c. =0.232, p < 0.05) and HDL cholesterol (s.c. = −0.203, p < 0.05) as independent determinant of ApoL1 levels, and the significant elevation of ApoL1 in metabolic syndrome. Lipoprotein fractionation analysis revealed the predominant distribution of ApoL1 in large HDL fraction, and the significant increase of ApoL1 in large LDL fraction in high ApoL1 samples with insulin resistance. In T2DM, ApoL1 was higher in T2DM with metabolic syndrome, however ApoL1 was lower with β cell dysfunction. Insulin significantly promotes ApoL1 synthesis and secretion in HepG2 cells. In conclusion, circulating ApoL1 may be associated with abnormal HDL metabolism in insulin resistant status. This may suggest a regulation of insulin signal on the ApoL1 level, leading to offer a novel insight to the ApoL1 biology.
• DOI: info:doi/10.1038/s41598-019-51367-7; https://doi.org/info:doi/10.1038/s41598-019-51367-7
• Persistent ID (NDL): info:ndljp/pid/11498500; https://dl.ndl.go.jp/pid/11498500
• Collection: 障害者向け資料
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• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-06-07T00:39:19+09:00
• Format (IMT): application/pdf
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/114663
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