Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal tension glaucoma

• Material Type: 博士論文
• ISSN: 2041-4889
• Title: Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal tension glaucoma
• Volume: 10
• Author/Editor: Sano, Hiroki; Namekata, Kazuhiko; Kimura, Atsuko; Shitara, Hiroshi; Guo, Xiaoli; Harada, Chikako; Mitamura, Yoshinori; Harada, Takayuki
• Author Heading: Sano, Hiroki; Namekata, Kazuhiko; Kimura, Atsuko; Shitara, Hiroshi; Guo, Xiaoli; Harada, Chikako; Mitamura, Yoshinori; Harada, Takayuki
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2019-01-28
• Publication Date (W3CDTF): 2019-01-28
• Alternative Title: 2種類の正常眼圧緑内障モデルマウスに対するN-アセチルシステインの網膜変性抑制効果の違い
• Periodical title: Cell Death & Disease
• Degree grantor/type: 徳島大学
• Date Granted: 2020-03-23
• Date Granted (W3CDTF): 2020-03-23
• Dissertation Number: 甲第3371号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3371号
• Text Language Code: eng
• Subject Heading: N-acetylcysteine; NTG; oxidative stress; EAAC1; GLAST
• Target Audience: 一般
• Note (General): N-acetylcysteine (NAC) is widely used as a mucolytic agent and as an antidote to paracetamol overdose. NAC serves as a precursor of cysteine and stimulates the synthesis of glutathione in neural cells. Suppressing oxidative stress in the retina may be an effective therapeutic strategy for glaucoma, a chronic neurodegenerative disease of the retinal ganglion cells (RGCs) and optic nerves. Here we examined the therapeutic potential of NAC in two mouse models of normal tension glaucoma, in which excitatory amino-acid carrier 1 (EAAC1) or glutamate/aspartate transporter (GLAST) gene was deleted. EAAC1 is expressed in retinal neurons including RGCs, whereas GLAST is mainly expressed in Müller glial cells. Intraperitoneal administration of NAC prevented RGC degeneration and visual impairment in EAAC1-deficient (knockout; KO) mice, but not in GLAST KO mice. In EAAC1 KO mice, oxidative stress and autophagy were suppressed with increased glutathione levels by NAC treatment. Our findings suggest a possibility that systemic administration of NAC may be available for some types of glaucoma patients.
• DOI: info:doi/10.1038/s41419-019-1365-z; https://doi.org/info:doi/10.1038/s41419-019-1365-z
• Persistent ID (NDL): info:ndljp/pid/11498503; https://dl.ndl.go.jp/pid/11498503
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-06-07T00:39:19+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/114666
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp