Relationship between fraction of exhaled nitric oxide and airway morphology assessed by threedimensional CT analysis in asthma

• Material Type: 博士論文
• ISSN: 2045-2322
• Title: Relationship between fraction of exhaled nitric oxide and airway morphology assessed by threedimensional CT analysis in asthma
• Volume: 7 1
• Author/Editor: 西本, 幸司
• Author Heading: 西本, 幸司
• Publication, Distribution, etc.: Nature Publishing Group
• Publication Date: 2017-08-31
• Publication Date (W3CDTF): 2017-08-31
• Alternative Title: 喘息患者における呼気一酸化窒素濃度と三次元CTで解析した気道構造の関連
• Periodical title: Scientific reports
• Degree grantor/type: 浜松医科大学
• Date Granted: 2020-03-16
• Date Granted (W3CDTF): 2020-03-16
• Dissertation Number: 甲第829号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第829号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Fraction of exhaled nitric oxide (FeNO) provides information about chronic inflammation in asthma. However, its relationship with structural changes in the airways is unknown. We aimed to evaluate the correlation between computer-based airway changes and FeNO in patients with asthma. The wall area (WA) and airway inner luminal area (Ai) of the third- to sixth-generation bronchi were measured using three-dimensional computed tomography in asthmatic patients. Each value was corrected by body surface area (BSA). Relationships between FeNO and WA/BSA and Ai/BSA were evaluated. Forty-one clinically stable patients with asthma were evaluated. FeNO was significantly correlated with WA/BSA of the third-, fourth-, fifth- and sixth-generation bronchi (Spearman correlation coefficient (ρ)=0.326, p=0.041; ρ=0.356, p=0.025; ρ=0.496, p=0.002; and ρ=0.529, p<0.001, respectively). The correlation with sixth-generation bronchi was significantly greater than with the third-generation bronchi (p=0.047). Partial rank correlation analysis indicated FeNO was significantly correlated with WA/BSA of the sixth-generation bronchi, independent from confounding factors of Ai/BSA, age, duration of asthma, dose of inhaled corticosteroid, blood eosinophil percentage, and blood IgE (ρ=0.360, p=0.034). In contrast, there was no correlation between FeNO and Ai/BSA. FeNO correlates with bronchial wall thickening in asthma patients. Measurement of FeNO may be useful to detect airway remodeling in asthma.
• DOI: info:doi/10.1038/s41598-017-10504-w; https://doi.org/info:doi/10.1038/s41598-017-10504-w
• Persistent ID (NDL): info:ndljp/pid/11498577; https://dl.ndl.go.jp/pid/11498577
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-06-07T00:39:19+09:00
• Date Created (W3CDTF): 2020-04-30
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003726; https://hama-med.repo.nii.ac.jp/records/3594
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-06 再収集