MDGA1-deficiency attenuates prepulse inhibition with alterations of dopamine and serotonin metabolism : An ex vivo HPLC-ECD analysis

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DOI[info:doi/10.1016/j.neulet.2019.134677]to the data of the same series

MDGA1-deficiency attenuates prepulse inhibition with alterations of dopamine and serotonin metabolism : An ex vivo HPLC-ECD analysis

Persistent ID (NDL): info:ndljp/pid/11498628

Material type: 博士論文

Author: Hossain, Md Razib

Publisher: -

Publication date: 2020-03-24

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: AbstractMDGA1 (MAM domain-containing glycosylphosphatidylinositol anchor) has recently been linked to schizophrenia and bipolar disorder. Dysregulatio...

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Material Type: 博士論文
Title: MDGA1-deficiency attenuates prepulse inhibition with alterations of dopamine and serotonin metabolism : An ex vivo HPLC-ECD analysis
Author/Editor: Hossain, Md Razib
Author Heading: Hossain, Md Razib
Publication Date: 2020-03-24
Publication Date (W3CDTF): 2020-03-24
Degree grantor/type: 香川大学
Date Granted: 2020-03-24
Date Granted (W3CDTF): 2020-03-24
Dissertation Number: 甲第733号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第733号
Text Language Code: eng
Alias of Author: Hossain, Md Razib
Subject Heading: MDGA1
Monoamines
Mouse brain
Prepulse inhibition
HPLC-ECD
Target Audience: 一般
Note (General): AbstractMDGA1 (MAM domain-containing glycosylphosphatidylinositol anchor) has recently been linked to schizophrenia and bipolar disorder. Dysregulation of dopamine (DA) and serotonin (5-HT) systems has long been associated with schizophrenia and other neuropsychiatric disorders. Here, we measured prepulse inhibition (PPI) of the startle response and ex vivo tissue content of monoamines and their metabolites in the frontal cortex, striatum and hippocampus of Mdga1 homozygous (Mdga1-KO), Mdga1 heterozygous (Mdga1-HT) and wild-type (WT) male mice. We found that Mdga1-KO mice exhibited statistically significant impairment of PPI, and had higher levels of homovanillic acid in all three brain regions studied compared with Mdga1-HT and WT mice (P < 0.05), while levels of norepinephrine, DA and its metabolites 3,4-dihydroxyphenylacetic acid and 3-methoxytyramine remained unchanged. Mdga1-KO mice also had a lower 5-hydroxyindoleacetic acid level in the striatum (P < 0.05) compared with WT mice. 5-HT levels remained unchanged with the exception of a significant increase in the level in the cortex. These data are the first evidence suggesting that MDGA1 deficiency leads to a pronounced deficit in PPI and plays an important role in perturbation of DA and 5-HT metabolism in mouse brain; such changes may contribute to a range of neuropsychiatric disorders.
DOI: info:doi/10.1016/j.neulet.2019.134677
https://doi.org/info:doi/10.1016/j.neulet.2019.134677
Persistent ID (NDL): info:ndljp/pid/11498628
https://dl.ndl.go.jp/pid/11498628
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2020-06-07T00:39:19+09:00
Date Created (W3CDTF): 2020-10-27
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/420
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp