Immunoreactivity of urate transporters, GLUT9 and URAT1, is located in epithelial cells of the choroid plexus of human brains

Persistent ID (NDL): info:ndljp/pid/11498629

Material type: 博士論文

Author: 植村, 直哉

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Publication date: 2020-03-24

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: AbstractIt has been suggested that urate plays a protective role in neurons, while hyperuricemia is correlated with atherosclerosis and cardiovascular...

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Material Type: 博士論文
Title: Immunoreactivity of urate transporters, GLUT9 and URAT1, is located in epithelial cells of the choroid plexus of human brains
Author/Editor: 植村, 直哉
Author Heading: 植村, 直哉
Publication Date: 2020-03-24
Publication Date (W3CDTF): 2020-03-24
Degree grantor/type: 香川大学
Date Granted: 2020-03-24
Date Granted (W3CDTF): 2020-03-24
Dissertation Number: 甲第731号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第731号
Text Language Code: eng
Alias of Author: Uemura, Naoya
Subject Heading: Choroid plexus
GLUT9
URAT1
Urate transporter
Target Audience: 一般
Note (General): AbstractIt has been suggested that urate plays a protective role in neurons, while hyperuricemia is correlated with atherosclerosis and cardiovascular disease. However, whether there is a system that directly transports urate into the brain remains to be clarified. In this study, the localization of glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1), which are known to be representative reabsorptive urate transporters, was immunohistochemically examined in autopsied human brains. Immunoreactivity of GLUT9 was observed on the apical side of the cytoplasm of epithelial cells in the choroid plexus and in the cilia of ependymal cells of the human brain. Immunoreactivity of URAT1 was observed on the basolateral side of the cytoplasm of epithelial cells in the choroid plexus. In addition, immunoreactivity of GLUT9 and URAT1 was not observed in microvessels of the human brains. The choroid plexus and renal proximal tubule were similar in having a polarized distribution of these two transporters with the two transporters on opposite membranes, but the two transporters’ distribution differs between the choroid plexus and the kidney in terms of which membrane (apical/basal) expresses which transporter. These findings support the hypothesis of the direct transport of intravascular urate into the central nervous system through the choroid plexus.
DOI: info:doi/10.1016/j.neulet.2017.09.001
https://doi.org/info:doi/10.1016/j.neulet.2017.09.001
Persistent ID (NDL): info:ndljp/pid/11498629
https://dl.ndl.go.jp/pid/11498629
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2020-06-07T00:39:19+09:00
Date Created (W3CDTF): 2020-10-27
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/418
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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