Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis 1

• Material Type: 博士論文
• ISSN: 2045-2322
• Title: Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis
• Volume: 9 1
• Author/Editor: Ferdous Urmi, Jeenat
• Author Heading: Ferdous Urmi, Jeenat
• Publication, Distribution, etc.: Nature Publishing Group
• Publication Date: 2019-11-19
• Publication Date (W3CDTF): 2019-11-19
• Alternative Title: Cidea, Cidec 遺伝子周辺におけるヒストン修飾の可塑性：発達期にプログラムされた肝脂肪変性が二次胆汁酸により改善する機序における関与
• Periodical title: Scientific reports
• Degree Grantor: 浜松医科大学
• Date Granted: 2019-12-13
• Date Granted (W3CDTF): 2019-12-13
• Dissertation Number: 甲第821号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第821号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; We recently reported that a treatment with tauroursodeoxycholic acid (TUDCA), a secondary bile acid, improved developmentally-deteriorated hepatic steatosis in an undernourishment (UN,40% caloric restriction) in utero mouse model after a postnatal high-fat diet (HFD). We performed a microarray analysis and focused on two genes (Cidea and Cidec) because they are enhancers of lipid droplet (LD) sizes in hepatocytes and showed the greatest up-regulation in expression by UN that were completely recovered by TUDCA, concomitant with parallel changes in LD sizes. TUDCA remodeled developmentally-induced histone modifications (dimethylation of H3K4, H3K27, or H3K36), but not DNA methylation, around the Cidea and Cidec genes in UN pups only. Changes in these histone modifications may contribute to the markedly down-regulated expression of Cidea and Cidec genes in UN pups, which was observed in the alleviation of hepatic fat deposition, even under HFD. These results provide an insight into the future of precision medicine for developmentally-programmed hepatic steatosis by targeting histone modifications.
• DOI: info:doi/10.1038/s41598-019-52943-7; https://doi.org/info:doi/10.1038/s41598-019-52943-7
• Persistent ID (NDL): info:ndljp/pid/11498769; https://dl.ndl.go.jp/pid/11498769
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-06-07T00:39:19+09:00
• Date Created (W3CDTF): 2020-04-28
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003718; https://hama-med.repo.nii.ac.jp/records/3586
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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