Conditioned media from human dental pulp stem cells prevent radiation-induced skin injury 33 1

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Conditioned media from human dental pulp stem cells prevent radiation-induced skin injury 1

Persistent ID (NDL): info:ndljp/pid/11511504

Material type: 博士論文

Author: Kawarabayashi, Keitaほか

Publisher: Shikoku Society of Dental Research

Publication date: 2020-06-12

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（歯学）

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Note (General)：: Radiation-induced skin ulceration is a frequent complication of radiotherapy for cancer treatment. Stem cells from human exfoliated deciduous teeth (S...

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Material Type: 博士論文
ISSN: 2189-6682
Title: Conditioned media from human dental pulp stem cells prevent radiation-induced skin injury
Volume: 33 1
Author/Editor: Kawarabayashi, Keita
Kano, Fumiya
Hashimoto, Noboru
Hibi, Hideharu
Iwamoto, Tsutomu
Yamamoto, Akihito
Author Heading: Kawarabayashi, Keita
Kano, Fumiya
Hashimoto, Noboru
Hibi, Hideharu
Iwamoto, Tsutomu
Yamamoto, Akihito
Publication, Distribution, etc.: Shikoku Society of Dental Research
Publication Date: 2020-06-12
Publication Date (W3CDTF): 2020-06-12
Alternative Title: ヒト歯髄幹細胞由来培養上清による皮膚の放射線障害の抑制効果
Dental pulp stem cell factors for treating RISR
Periodical title: Journal of Oral Health and Biosciences
Degree grantor/type: 徳島大学
Date Granted: 2020-03-23
Date Granted (W3CDTF): 2020-03-23
Dissertation Number: 甲第3382号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第3382号
Text Language Code: eng
Subject Heading: human dental pulp stem cells
conditioned media
mesenchymal stem cells
radiation-induced skin reaction
cutaneous radiation syndrome
radiation-induced skin reactions
Target Audience: 一般
Note (General): Radiation-induced skin ulceration is a frequent complication of radiotherapy for cancer treatment. Stem cells from human exfoliated deciduous teeth (SHEDs) can regenerate various tissues. In this study, we investigated the impact of SHED-conditioned media (SHED-CM) on radiation-induced ulceration. Mouse necks were locally irradiated with a single dose of 15 Gy of radiation. A week after the irradiation, most of the wild-type mice generated ulcer surrounded by severe erythema. Intra-venous administration of SHED-CM effectively inhibited the ulcer formation. Histological examination revealed that SHED-CM treatment inhibited radiation-induced dermal thickness and epithelial hyperplasia. SHED-CM could be a useful treatment option for radiation-induced skin ulceration.
DOI: info:doi/10.20738/johb.33.1_1
https://doi.org/info:doi/10.20738/johb.33.1_1
Persistent ID (NDL): info:ndljp/pid/11511504
https://dl.ndl.go.jp/pid/11511504
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2020-07-06T20:31:19+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/114712
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp