Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosrcoma

• Material Type: 博士論文
• Title: Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosrcoma
• Author/Editor: Okuno, Kazuma
• Author Heading: Okuno, Kazuma
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2020-03-25
• Publication Date (W3CDTF): 2020-03-25
• Degree grantor/type: 三重大学
• Date Granted: 2020-03-25
• Date Granted (W3CDTF): 2020-03-25
• Dissertation Number: 乙医学第1049号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 乙医学第1049号
• Text Language Code: eng
• Alias of Author: オクノ, カズマ; 奥野, 一真
• Subject Heading: hypoxia; osteosarcoma; carbonic anhydrase IX; inhibitor\n
• Target Audience: 一般
• Note (General): application/pdf; Purpose: We investigated the effect of carbonic anhydrase IX (CA IX) inhibitor under hypoxia and normoxia in SaOS2 human osteosarcoma cell line. We also evaluated the expres- sion of CA IX in 27 patients diagnosed with osteosarcoma.Materials and methods: CA IX expression in SaOS2 cells cultured under different oxygen tensions was analyzed by Western blotting. To evaluate the effect of CA IX inhibitor, MTS cell viability assay was performed after cells were treated with various concentrations of doxorubicin with or without a CA IX inhibitor. Finally, CA IX expression in patient-derived osteosarcoma samples was evaluated by immunohistochemistry.Results: Treatment with CA IX inhibitor significantly suppressed cell proliferation and migration under hypoxic conditions. CA IX expression was observed in 81% of 27 patients. The 5-year survival rates in patients with high and low stain scores were 43.8% and 81.8%, respectively.Conclusion: CA IX inhibitors have the potential to suppress cell proliferation, migration, and chemoresistance.; 本文/Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan; 8p
• DOI: info:doi/10.2147/OTT.S177605; https://doi.org/info:doi/10.2147/OTT.S177605
• Persistent ID (NDL): info:ndljp/pid/11511867; https://dl.ndl.go.jp/pid/11511867
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-07-06T20:31:19+09:00
• Date Created (W3CDTF): 2020-06-09
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00019079; https://mie-u.repo.nii.ac.jp/records/13460
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2020-09-04 再収集