CADM1 is a diagnostic marker in early-stage mycosis fungoides : Multicenter study of 58 cases

Persistent ID (NDL): info:ndljp/pid/11512034

Material type: 博士論文

Author: Yuki, Akihiko

Publisher: -

Publication date: 2019-09-20

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 新潟大学,博士（医学）

View All

Notes on use at the National Diet Library

本資料は、掲載誌(URI)等のリンク先にある学位授与機関のWebサイトやCiNii Dissertationsから、本文を自由に閲覧できる場合があります。

Notes on use

Note (General)：: Background: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. Early-stage MF patches or plaques often resemble inflammatory skin di...

Search by Bookstore

Read this material in an accessible format.

View materials in accessible formats for people with print disabilities (1Type)

Search by Bookstore

Read in Disability Resources

Other Services
- テキストデータ check it on 国立国会図書館デジタルコレクション

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 博士論文
Title: CADM1 is a diagnostic marker in early-stage mycosis fungoides : Multicenter study of 58 cases
Author/Editor: Yuki, Akihiko
Publication Date: 2019-09-20
Publication Date (W3CDTF): 2019-09-20
Alternative Title: 早期菌状息肉症の診断におけるCADM1の有用性についての検討
Degree grantor/type: 新潟大学
Date Granted: 2019-09-20
Date Granted (W3CDTF): 2019-09-20
Dissertation Number: 甲第4627号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第4627号
Text Language Code: eng
Subject Heading: adult T-cell leukemia/lymphoma
cell adhesion molecule 1
cutaneous T-cell lymphoma
mycosis fungoides
Note (General): Background: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. Early-stage MF patches or plaques often resemble inflammatory skin disorders (ISDs), including psoriasis and atopic dermatitis. Cell adhesion molecule 1 gene (CADM1), which was initially identified as a tumor suppressor gene in human non-small cell lung cancer, has been reported as a diagnostic marker for adult T-cell leukemia/lymphoma. Objective: We investigated CADM1 expression in MF neoplastic cells, especially during early stages, and evaluated its usefulness as a diagnostic marker for MF. Methods: We conducted a retrospective study by using immunohistochemical staining and confirmed the expression of CADM1 in MF. In addition, we compared CADM1 messenger RNA expression in microdissected MF samples and ISD samples. Results: In the overall study period, 55 of 58 MF samples (94.8%) stained positive for CADM1. None of the 50 ISD samples showed positive reactivity (P<.0001). We found CADM1 messenger RNA expression in the intradermal lymphocytes of patients with MF but not in those of patients with an ISD. Limitations: We did not conduct a validation study for MF cases in other institutions. Conclusions: CADM1-positive cells can be identified in early stages with fewer infiltrating cells and may be useful as a diagnostic marker for early-stage MF. (J Am Acad Dermatol 2018;79:1039-46.)
J Am Acad Dermatol. 2018, 79(6), 1039-1046.
新大院博（医）甲第887号
元資料の権利情報 : 【○!C】 2018 by the American Academy of Dermatology, Inc.
DOI: info:doi/10.1016/j.jaad.2018.06.025
https://doi.org/info:doi/10.1016/j.jaad.2018.06.025
Persistent ID (NDL): info:ndljp/pid/11512034
https://dl.ndl.go.jp/pid/11512034
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2020-07-06T20:31:19+09:00
Date Created (W3CDTF): 2020-06-10
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/00051651
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp