Alternative Title外来通院中の日本人リウマチ性疾患患者における不眠とレストレスレッグス症候群の有病率の横断研究
Degree grantor/typeNagasaki University (長崎大学)
Note (General)The prevalence of symptomatic insomnia and the prevalence of restless legs syndrome (RLS) are known to be higher among patients with rheumatic diseases compared to the general population. The prevalences of insomnia and RLS reported in a questionnaire by Japanese patients with rheumatic diseases at an outpatient clinic were analyzed herein. The association between the patients' disease activity and their sleep quality was analyzed. Of 121 rheumatic disease patients, 70 were enrolled. The median (interquartile range) age at enrollment was 62.0 (47.8?68.0) years. There were 58 women (82.9%) and 12 men (17.1%), and 43 patients (61.4%) with rheumatoid arthritis (RA), nine (12.9%) with systemic lupus erythematosus (SLE), and 18 (25.7%) with other rheumatic diseases. Twenty patients (28.6%) had one or more moderate-to-severe insomnia symptoms, and 10 (14.3%) were diagnosed with RLS. Among the patients with RA, the swollen joint count based on a 28-joint assessment (SJC28) was significantly higher in the insomnia group (n = 13) compared to the non-insomnia group (n = 30) (p = 0.006). A classification and regression tree (CART) analysis showed that the cut-off points of ?3 mg/day prednisolone (PSL) treatment and <16.54% as the transferrin saturation (TSAT) value would best predict RLS in rheumatic disease. Patients with rheumatic disease had a high prevalence of symptomatic insomnia and RLS. A higher dose of PSL and lower TSAT were associated with the occurrence of RLS.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1253号 学位授与年月日:令和2年6月3日
Author: Kayoko Urashima, Kunihiro Ichinose, Hideaki Kondo, Takahiro Maeda, Atsushi Kawakami, Hiroki Ozawa
Citation: PLoS ONE, 15(3), e0230273; 2020
identifier:Nagasaki University (長崎大学), 博士(医学) (2020-06-03)
http://hdl.handle.net/10069/40080
DOIinfo:doi/10.1371/journal.pone.0230273
Collection (particular)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Date Accepted (W3CDTF)2020-07-06T20:31:19+09:00
Data Provider (Database)国立国会図書館 : 国立国会図書館デジタルコレクション