Alternative Title非小細胞肺癌に対する肺切除術後の運動耐容能に影響を及ぼす要因
Periodical titleIntegrative Cancer Therapies
Degree grantor/typeNagasaki University (長崎大学)
Note (General)Purpose: We investigated, in patients who underwent lung resection for non?small cell lung cancer (NSCLC), the magnitude of early limitation in functional exercise capacity and the associations with pre- and postoperative factors. Methods: Consecutive patients with preoperative clinical stage I to IIIA NSCLC who underwent lung resection were prospectively enrolled. We measured functional exercise capacity (6-minute walk distance [6MWD]) and skeletal muscle strength (handgrip [HF] and quadriceps force [QF]) within 2 days prior to surgery and on day 7 postoperatively. Results: Two hundred eighteen participants were recruited (median age 69 years) of whom 49 developed postoperative complications (POCs). 6MWD was markedly decreased (514 m vs 469 m, P < .001); HF and QF were slightly decreased following surgery. Multiple linear regression showed that preoperative vital capacity (P < .01), QF (P < .05), the duration of chest tube drainage (P < .001), and presence of POCs (P < .05) were significant predictors. However, intraoperative factors were not significantly associated with the decline in 6MWD. Conclusions: These results suggest that patients with preoperative impairments in pulmonary function and muscle strength, and those who require prolonged chest tube drainage or develop POCs are likely to have impaired exercise capacity. Therefore, individual assessment and follow-up of patients with such factors is indicated.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1260号 学位授与年月日:令和2年6月3日
Author: Masato Oikawa, Masatoshi Hanada, Hiroki Nagura, Tomoshi Tsuchiya, Keitaro Matsumoto, Takuro Miyazaki, Terumitsu Sawai, Naoya Yamasaki, Takeshi Nagayasu, Ryo Kozu
Citation: Integrative Cancer Therapies, 19, 1534735420923389; 2020
identifier:Nagasaki University (長崎大学), 博士(医学) (2020-06-03)
http://hdl.handle.net/10069/40087
DOIinfo:doi/10.1177/1534735420923389
Collection (particular)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Date Accepted (W3CDTF)2020-07-06T20:31:19+09:00
Data Provider (Database)国立国会図書館 : 国立国会図書館デジタルコレクション